Additionally, another exception occurred while executing the custom error page for the first exception. Applies to hydroxychloroquine: oral tablet Along with its needed effects, hydroxychloroquine (the active ingredient contained in Plaquenil) may cause some unwanted effects. Can plaquenil cause macular degeneration Dosage of plaquenil for lichen planopilaris Chloroquine calcium phosphate transfection Hydroxychloroquine blood monitoring Hydroxychloroquine retinopathy was followed for 5 years to 8 years in patients off the drug for as long as 20 years. Ellipsoid zone length, autofluorescence images, and visual acuity stabilized in mild retinopathy. Severe retinopathy retinal pigment epithelial damage progressed steadily, much like retinal dystrophies. Is there really a scarcity in cases, though? New information shows that hydroxychloroquine retinal toxicity occurs 7.5 percent of the time, which is not that rare. 3. In those patients who are affected, their daily dose and duration of use varied widely. Chloroquine and hydroxychloroquine bind to melanin in the retinal pigment epithelium RPE and cause damage to the macular cones outside of the fovea. The drugs inhibit RPE lysosome activity, reduce phagocytosis of shed photoreceptor outer segments causing an accumulation of outer receptor segments. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Although not all of these side effects may occur, if they do occur they may need medical attention. Hydroxychloroquine retinal deposits Plaquenil What You Need to Know - Kaleidoscope Fighting Lupus, Determine risk for hydroxychloroquine retinal toxicity Optometry Times How effective is chloroquinePlaquenil brand name vs genericChloroquine how does it workHydroxychloroquin sulphate Diagnosis Hydroxychloroquine-induced retinal toxicity Discussion. Chloroquine CQ and hydroxychloroquine Plaquenil HCQ have been used for many years, initially for the treatment of malaria but now more commonly for the treatment of inflammatory diseases such as rheumatoid arthritis and lupus 1. Hydroxychloroquine Plaquenil Toxicity and Recommendations.. Chloroquine And Hydroxychloroquine Toxicity - StatPearls.. Hydroxychloroquine-related retinal toxicity Rheumatology Oxford.. I have Chloroquine retinopathy deposits on the macula in both eyes after taking Hydroxychloroquine Sulphate for three and a half years for RA. I wasn't offered an eye test at the hospital before starting on this drug, but I was going to Boots Opticians to have an annual eye exam and digital retinal photo. Advanced hydroxychloroquine toxicity presents as a bullseye maculopathy. Since retinal toxicity is usually irreversible, early detection of retinal toxicity and cessation of the offending agent is the best treatment. Corneal toxicity presents as an intraepithelial deposition of the drug into the cornea, which rarely affects vision. Chloroquine has a very high volume of distribution, as it diffuses into the body's adipose tissue. Chloroquine and related quinines have been associated with cases of retinal toxicity, particularly when provided at higher doses for longer times. Accumulation of the drug may result in deposits that can lead to blurred vision and blindness.