Chloroquine was first discovered in the 1930s in Germany and began to be widely used as an anti-malaria post-World War II, in the late 1940s. However, resistance to the drug also rapidly emerged, with the first cases of not being cured by administration of chloroquine being reported in the 1950s. Antimalarial drugs hydroxychloroquine Hydroxychloroquine dosing guidelines Chloroquine should not be used for treatment of P. falciparum infections from areas of chloroquine resistance or malaria occurring in patients where chloroquine prophylaxis has failed. Patients infected with a resistant strains of plasmodia should be treated with another antimalarial drug. However, the efficiency of chloroquine has been severely impacted by the recent development of chloroquine resistant plasmodium falciparum parasites. The development of chloroquine resistance by malaria parasites is increasing at an alarming rate especially in the tropical countries where it is used extensively as an antimalarial drug 2. The spread of chloroquine-resistant falciparum malaria in Africa was responsible for a sharp increase in malaria morbidity and mortality 2, 3. Resistance to chloroquine is modulated by the P. falciparum chloroquine resistance transporter PfCRT gene. Nowadays, other drugs, and notably ones containing artemisinin-based compounds, are preferentially used to treat uncomplicated malaria and especially in areas where chloroquine resistance is known to occur. Since then, resistance has spread rapidly (since obviously it is beneficial to the parasite to be resistant, so various mutations conferring this protection have arisen multiple times in different areas in the world and also been passed on preferentially to new generations of malaria parasites), and now chloroquine resistant are found in multiple locations in south-east Asia, such as Myanmar and India, as well as from Guyana in South America. Is p falciparum chloroquine resistant Plasmodium falciparum chloroquine resistance transporter is a., Chloroquine Resistance in Plasmodium falciparum - microbewiki Will plaquenil help anemiaPlaquenil and thinning outer nuclear layer of retinaPlaquenil which company The rapid shift in P. falciparum from CQ-resistant to CQ-susceptible suggests that the removal of CQ for the treatment of P. falciparum or the pressure from AL that has been used since 2004 to treat falciparum malaria and mixed infection of P.falciparum and P. vivax or both may eventually lead to replacement of pfmdr1 resistance genes by susceptible parasite populations 42, 57. Return of chloroquine-sensitive Plasmodium falciparum.. The return of chloroquine-susceptible Plasmodium.. Malaria understanding drug resistance - BugBitten. In most parts of the world, P. falciparum is resistant to chloroquine, and the recommended treatment is artemisinin bases combinations. Primaquine should be used in P. vivax and P. ovale malaria for eradicating the persisting liver forms and in P. falciparum malaria to destroy the gametocytes, so as to prevent the spread of infection. Chloroquine-resistant Plasmodium falciparum is endemic in many areas. Saudi Arabia was considered to have chloroquine-susceptible P. falciparum. During the 1997–1998 season, an outbreak of. Haiti has been a remarkable outlier as a country in which P. falciparum malaria is endemic without evidence of chloroquine CQ resistance 3,6–8. Even though Haiti has had no comprehensive national malaria control program for 20 years 9, several reports have found no evidence of CQ resistance in Haiti 3,6–8.