Chloroquine skin pigmentation

Discussion in 'Plaquenil 200mg' started by andaim, 11-Mar-2020.

  1. ruswater Guest

    Chloroquine skin pigmentation


    In many cases, once the offending drug has been stopped, fading of the lesions occurs. However, the pigmentation may last a long time or become permanent.

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    Chloroquine Phosphate. Chloroquine is used to prevent or treat malaria caused by mosquito bites in countries where malaria is common. Malaria parasites can enter the body through these mosquito bites, and then live in body tissues such as red blood cells or the liver. Chloroquine, hydrocychloroquine, amodiaquine and quinacrine are all example of antimalarials which can cause skin pigmentation. What does the skin pigmentation look like? Usually, when you start taking antimalarials, the areas of skin pigmentation which they can cause are small and oval in shape. As you take more antimalarials, the skin pigmentation will usually develop into large patches of discolouration. The skin lesions were macular or patchy, some well and others poorly demarcated, with a hyperpigmentation of gray to black discoloration, generally annular, but some with irregular morphology. They were flat without induration or scaling. A diagnosis of HCQ-associated hyperpigmentation was made, and HCQ was discontinued.

    Authors: Dr Anes Yang, Clinical Researcher, Department of Dermatology, St George Hospital, University of New South Wales, Sydney, NSW, Australia; Dr Monisha Gupta, Senior Staff Specialist, Department of Dermatology, Liverpool Hospital, Sydney, NSW, Australia. It is a hydroxylated version of chloroquine, with a similar mechanism of action. Because many drugs that induce skin pigmentation also cause photosensitivity reactions, sun protection is usually recommended.

    Chloroquine skin pigmentation

    Drug-induced hyperpigmentation DermNet NZ, Antimalarial Induced Skin Pigmentation

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  6. Jul 30, 2019 Several cases of hypopigmentation of the skin have been reported. Most of the patients described were African or of African descent with dark skin who had been exposed to the sun. One was a Hispanic patient who developed vitiligo-like skin depigmentation after 1 month of chloroquine therapy for cutaneous lupus erythematosus. The skin rapidly repigmented after discontinuation of chloroquine therapy.

    • Chloroquine Side Effects Common, Severe, Long Term -.
    • Hydroxychloroquine-induced Hyperpigmentation of the Skin..
    • Chloroquine - Wikipedia.

    Skin pigmentation can be due to variety of drugs that can arise due to direct effects of the drugs as in combination with triggering factors like sun exposure. Out of several drugs some of the most common drugs that cause skin pigmentation are antimalarials drugs, tetracyclines, nonsteroidal anti-inflammatory drugs, cytotoxic drugs, amiodarone. Chloroquine is an anti-malaria medicine that works by interfering with the growth of parasites in the red blood cells of the human body. Parasites that cause malaria typically enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia. Desorption of chloroquine and hydroxychloroquine from Sepia melanin. Initially 5 mg of melanin was saturated by equilibration with 5 mL of 1.9 mmol/L chloroquine prepared in 20 mM potassium phosphate buffer at pH 7.4 for 2 h. The samples were then centrifuged at 477 × g for 4 min and the supernatant removed.

     
  7. foikever Well-Known Member

    A 45-year-old black female presented with no ocular or visual complaints. However, her medical history was significant for a recent diagnosis of lupus. Plaquenil Oral Uses, Side Effects, Interactions. The Facts on Fasting for Blood Tests - WebMD Hydroxychloroquine Side Effects, Dosage, Uses, and More
     
  8. SaintP Well-Known Member

    Sulfasalazine Oral Route Precautions - Mayo Clinic Check with your doctor right away if you or your child have a fever and sore throat, pale skin, unusual bruising or bleeding, or unusual tiredness or weakness. These may be symptoms of a blood problem. This medicine may decrease the amount of sperm men make and affect their ability to have children.

    Side effects of hydroxychloroquine, does plaquenil cause bruising
     
  9. pro-jet Moderator

    Hydroxychloroquine Plaquenil Side Effects & Dosage for Malaria Combining telbivudine Tyzeka and hydroxychloroquine may increase the risk of unexplained muscle pain, tenderness, or weakness because both drugs cause such side effects. Hydroxychloroquine suppresses the immune system and should not be combined with drugs that also suppress the immune system or live vaccines.

    Hydroxychloroquine Information for Providers AIDSinfo