In many cases, once the offending drug has been stopped, fading of the lesions occurs. However, the pigmentation may last a long time or become permanent. Cerebral malaria lithium and plaquenil Dosing of aralen Best way to monitor patients for plaquenil Chloroquine Phosphate. Chloroquine is used to prevent or treat malaria caused by mosquito bites in countries where malaria is common. Malaria parasites can enter the body through these mosquito bites, and then live in body tissues such as red blood cells or the liver. Chloroquine, hydrocychloroquine, amodiaquine and quinacrine are all example of antimalarials which can cause skin pigmentation. What does the skin pigmentation look like? Usually, when you start taking antimalarials, the areas of skin pigmentation which they can cause are small and oval in shape. As you take more antimalarials, the skin pigmentation will usually develop into large patches of discolouration. The skin lesions were macular or patchy, some well and others poorly demarcated, with a hyperpigmentation of gray to black discoloration, generally annular, but some with irregular morphology. They were flat without induration or scaling. A diagnosis of HCQ-associated hyperpigmentation was made, and HCQ was discontinued. Authors: Dr Anes Yang, Clinical Researcher, Department of Dermatology, St George Hospital, University of New South Wales, Sydney, NSW, Australia; Dr Monisha Gupta, Senior Staff Specialist, Department of Dermatology, Liverpool Hospital, Sydney, NSW, Australia. It is a hydroxylated version of chloroquine, with a similar mechanism of action. Because many drugs that induce skin pigmentation also cause photosensitivity reactions, sun protection is usually recommended. Chloroquine skin pigmentation Drug-induced hyperpigmentation DermNet NZ, Antimalarial Induced Skin Pigmentation Plaquenil biofilmPlaquenil genetic contraindicatedChloroquine overdose treatmentHydroxychloroquine affects retina Jul 30, 2019 Several cases of hypopigmentation of the skin have been reported. Most of the patients described were African or of African descent with dark skin who had been exposed to the sun. One was a Hispanic patient who developed vitiligo-like skin depigmentation after 1 month of chloroquine therapy for cutaneous lupus erythematosus. The skin rapidly repigmented after discontinuation of chloroquine therapy. Chloroquine Side Effects Common, Severe, Long Term -. Hydroxychloroquine-induced Hyperpigmentation of the Skin.. Chloroquine - Wikipedia. Skin pigmentation can be due to variety of drugs that can arise due to direct effects of the drugs as in combination with triggering factors like sun exposure. Out of several drugs some of the most common drugs that cause skin pigmentation are antimalarials drugs, tetracyclines, nonsteroidal anti-inflammatory drugs, cytotoxic drugs, amiodarone. Chloroquine is an anti-malaria medicine that works by interfering with the growth of parasites in the red blood cells of the human body. Parasites that cause malaria typically enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia. Desorption of chloroquine and hydroxychloroquine from Sepia melanin. Initially 5 mg of melanin was saturated by equilibration with 5 mL of 1.9 mmol/L chloroquine prepared in 20 mM potassium phosphate buffer at pH 7.4 for 2 h. The samples were then centrifuged at 477 × g for 4 min and the supernatant removed.