Clonidine sedation

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    Clonidine sedation


    Study Objective: To determine the effects of oral clonidine premeditation sedative, anxiolytic, and hemodynamic responses during the immediate preoperative period, laryngoscopy/intubation, and postanesthetic recovery. Design: Randomized double-blind assignment to one of four treatment groups (clonidine 0.1 mg, clonidine 0.2 mg, triazolam 0.25 mg, or placebo); n = 10 per group. Setting: Inpatient surgery in a university-staffed tertiary center. Patients: Forty ASA physical status I and II adults of both sexes scheduled, for a variety of procedures requiring general anesthesia. Interventions: Anxiety and sedation scored on ordinal scale at time of treatment and 90 minutes later, just prior to anesthetic induction. Standardized induction protocol with automated hemodynamic monitoring at 1-minute intervals and a 45-second laryngoscopy to ensure a vigorous stress response. Measurements and Main Results: Triazolam and both closes of clonidine increased sedation at 90 minutes both absolutely and compared with a placebo. Introduction Sedation is an essential part of paediatric critical care. Midazolam, often in combination with opioids, is the current gold standard drug. However, as it is a far-from-ideal agent, clonidine is increasingly being used in children. This drug is prescribed off-label for this indication, as many drugs in paediatrics are. Therefore, the CLOSED trial aims to provide data on the pharmacokinetics, safety and efficacy of clonidine for the sedation of mechanically ventilated patients in order to obtain a paediatric-use marketing authorisation. Methods and analysis The CLOSED study is a multicentre, double-blind, randomised, active-controlled non-inferiority trial with a 1:1 randomisation between clonidine and midazolam. Both treatment groups are stratified according to age in three groups with the same size: Ethics Written informed consent will be obtained from the parents/caregivers.

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    Clonidine may cause drowsiness or sedation as a side effect. Still, there’s not enough research to support it as a safe treatment for insomnia. Learn more. Apr 1, 2008. Sedation allows the depression of patients' awareness of the environment. Clonidine, Analgesia; anxiolysis; minimal respiratory depression. Clonidine. We set out to perform a systematic review on the efficacy of clonidine as a sedative agent in adult patients on the intensive care unit. A comprehensive.

    Dexmedetomidine, sold under the trade name Precedex among others, is an anxiety reducing, sedative, and pain medication. Dexmedetomidine is notable for its ability to provide sedation without risk of respiratory depression (unlike other commonly used sedatives such as propofol, fentanyl, and midazolam) and can provide cooperative or semi-arousable sedation. Similar to clonidine, it is an agonist of α Dexmedetomidine is most often used in the intensive care setting for light to moderate sedation. A feature of dexmedetomidine is that it has analgesic properties in addition to its role as a hypnotic, but is opioid sparing; thus, it is not associated with significant respiratory depression (unlike propofol). Many studies suggest dexmedetomidine for sedation in mechanically ventilated adults may reduce time to extubation and ICU stay. It can be used as an adjunct with other sedatives like benzodiazepines, opioids, and propofol to enhance sedation and help maintain hemodynamic stability by decreasing the requirement of other sedatives. Intravenous infusion of dexmedetomidine is commonly initiated with a loading dose followed by a maintenance infusion. There may be great individual variability in the hemodynamic effects (especially on heart rate and blood pressure), as well as the sedative effects of this drug. Background Sedation is an important treatment for critically ill patients who need a machine to support breathing, because it reduces anxiety and stress and facilitates the delivery of nursing care. However, some commonly-used sedatives, such as , midazolam and lorazepam, might decrease blood pressure, depress breathing, and delay awakening after a long-term infusion. They may prolong breathing support time and length of stay in hospital. Dexmedetomidine and clonidine sedate but allow staff to interact with patients, and they ease pain but do not depress breathing. Those treated with them could be more easy to awake, and more able to communicate their discomfort and pain. These drugs are therefore attractive alternatives for long-term , midazolam and lorazepam. We found no eligible studies in children or for clonidine.

    Clonidine sedation

    Clonidine and sedation - MedHelp, Sedation in the intensive care unit BJA Education Oxford Academic

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  4. RATIONALE. Clonidine is an alpha-2 selective adrenergic agonist that may be a safe and effective sedative agent in the intensive care unit ICU. In order.

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    Commonly reported side effects of clonidine include drowsiness, fatigue, hypotension, lethargy, sedated state, headache, and upper abdominal pain. Other side effects include dizziness. See below for a comprehensive list of adverse effects. Along with its needed effects, clonidine may cause some. Oct 27, 2016. Clonidine may cause drowsiness or sedation as a side effect. Still, there's not enough research to support it as a safe treatment for insomnia. Clonidine also significantly lowered Ramsay sedation scores and patients were extubated 24-48 hours after starting treatment. However this was an interventional cohort study. There was no randomisation; no blinding and the 5 non-responders to clonidine treatment were excluded from the analyses 36 Table 1.

     
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