It's used to treat and prevent malaria infection, and to reduce symptoms and progression of autoimmune diseases such as lupus, rheumatoid arthritis, and others. Malaria is spread by mosquitoes, which transmit the parasites that cause the infection, usually in tropical and subtropical parts of the world. Chloroquin toxicity Rash caused by plaquenil Retinal damage plaquenil Adults. 200 mg 155 mg base to 400 mg 310 mg base PO per day, administered as a single dose or in 2 divided doses. Antimalarials and/or glucocorticoids are of benefit and may be used for the treatment of SLE without major organ manifestations; however, judicious use of hydroxychloroquine is recommended. Methotrexate and plaquenil. now been given plaquenil 400mg daily, has anyone else been on this mixture and has it worked or how long should i wait to see if it works. i am still in so much pain everyday and hoping for some relieve soon. Plaquenil vs Methotrexate I was diagnosed with RA a month ago and am returning to my Rheumatologist tomorrow to discuss treatment options. The doctor said that given where I am right now constant low level pain and light swelling of my hands and wrists but no joint damage showing up on xrays or the ultrasound, she gave me a choice of starting. For example, it may be combined with an antibiotic to treat chronic Q-fever, which humans usually catch from farm animals or raw milk. Plaquenil is used to treat other types of infections too. Plaquenil and methotrexate together Hydroxychloroquine and methotrexate Drug Interactions - RxList, Methotrexate and plaquenil - Plaquenil effects on liverHydroxychloroquine and allergy testingCan plaquenil be taken with neurontinChloroquine antimalarialPlaquenil 200 mg oral tablet Learn about drug interactions between hydroxychloroquine oral and methotrexate sodium oral and use the RxList drug interaction checker to check drug combinations. Drugs A-Z Pill Identifier Supplements Symptom Checker Diseases Dictionary Media Hydroxychloroquine oral and methotrexate sodium oral Drug.. Plaquenil vs Methotrexate rheumatoid. Compare Methotrexate vs Plaquenil for Lupus.. Plaquenil is the brand name for the prescription drug hydroxychloroquine. It's used to treat and prevent malaria infection, and to reduce symptoms and progression of autoimmune diseases such as lupus, rheumatoid arthritis, and others. Sorry to hear that you are having a lot of pain with your RA. I have lupus which mainly affects my joints and skin. I have been taking hydroxychloroquine which is the generic of plaquenil for the past three years. My rheumy recently added Imuran instead of methotrexate. Plaquenil hydroxychloroquine takes up to 3 months to begin working. A more chronic form of interstitial lung disease and fibrosis is also seen in patients with rheumatoid arthritis. This may be increased with methotrexate. Myelosuppression lowering of blood counts is also rare at the low doses of methotrexate utilized for rheumatoid arthritis. Patients at particular risk include those with renal insufficiency from other causes or use of trimethoprim Bactrim®, Septra® which increases levels of methotrexate.