Listed below are ongoing research studies, currently seeking participants, that have a special focus on early identification of autism and other developmental disorders. We are continuing to develop and validate a screening tool for ASD, the Modified Checklist for Autism in Toddlers (M-CHAT) (Robins, Fein, Green and Barton, Journal of Autism and Developmental Disorders, April, 2001), and investigating the properties of a second screening tool, the Yale Screener (Volkmar, Klin, and Chawarska). To learn more about these studies, please contact the individuals listed below. See the e Website for additional information on the M-CHAT. Location: University of California San Diego and Rady Childrens Hospital Autism Discovery Institute Principal Investigator: Jonathan Sebat, Ph D Co-Investigator: Christina Corsello, Ph D Co-Investigator: Natacha Akshoomoff, Ph D With funding from: Simons Foundation Autism Research Initiative The REACH Project is a genetic research collaboration between the UCSD Department of Psychiatry and Rady Childrens Hospital Autism Discovery Institute. These screening tools are parent questionnaire instruments designed for children aged 16 to 30 months. Our study aim is to relate genetic variations to neurodevelopment in children. They are administered in a pediatrician’s office and take only a few minutes to complete. We hope to learn more about how genetic variations influence brain development, and in what ways these variations may contribute to specific developmental conditions. They are sent to the University of Connecticut in an envelope provided, and scored by us. Involvement includes a single 1 hour appointment with completion of developmental questionnaires by parents, non-invasive 3D image of your childs head, and a simple blood draw. Institute, research on neurodevelopmental disorders is conducted in three primary areas: behavioral, biological and intervention studies. If a child fails the screening, the parent is called and asked about the failed items. If a genetic variation of interest to our study is found, you may be contacted for further participation. If the child still fails, the family is offered a free developmental and diagnostic evaluation at the University of Connecticut, at the Yale Child Study Center, or in a Springfield, Ma. This evaluation is done within a few weeks, bypassing the waiting lists at the evaluation sites. Fluoxetine is frequently used to treat major depressive disorder, obsessive–compulsive disorder (OCD), post-traumatic stress disorder (PTSD), bulimia nervosa, panic disorder, premenstrual dysphoric disorder, and trichotillomania. The effectiveness of fluoxetine and other antidepressants in the treatment of mild-to-moderate depression is controversial. A review of the comparative efficacy of 21 antidepressant drugs found that fluoxetine was among the least effective for treatment of depression. A 2009 meta-analysis by Fournier which evaluated patient-level data from six trials of the SSRI paroxetine and the non-SSRI antidepressant imipramine has been further cited as evidence that antidepressants exhibit minimal efficacy in mild to moderate depression. A 2012 meta-analysis using individual patient level-data of fluoxetine for the treatment of depression concluded statistically and clinically significant benefit was seen irrespective of baseline depression severity, and no significant effect was found on baseline severity on observed efficacy. A 2009 systematic review by the National Institute of Care and Clinical Excellence (NICE) (which considered the Kirsch, but not the later meta-analyses) concluded strong evidence existed for the efficacy of SSRIs in the treatment of moderate and severe depression, with some evidence for their efficacy in the treatment of mild depression. Both the NICE and the Fournier analyses concluded that greater evidence is seen for the efficacy of antidepressants in the treatment of chronic mild depression (dysthymia) than in recent-onset mild depression. 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