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Pharmacological group: thyroid hormones; synthetic natural thyroid hormones. Pharmacological action: treatment of hypothyroidism. IUPAC name: (S) -2-amino-3- [4- (4-hydroxy-3,5-diiodophenoxy) -3,5-diiodophenyl] propanoic acid Other names: 3,5,3 ', 5'- tetradiodo-L-thyronin Bioavailability ~ 100% Application: oral, intravenous Metabolism: mainly in the liver, kidneys, brain and muscles Half-life period: approx. 7 days (for hyperthyroidism 3-4 days, for hypothyroidism 9-10 days) Excretion: with feces and urine Legal Status: Prescription only Molecular formula: C15H11I4NO4 Molar mass: 776.87 g mol-1 Melting point: 231-233 ° C Solubility in water: slightly soluble substance (0105 mg · l -1 at 25 ° С). Levothyroxine sodium is a synthetic form of the natural thyroid hormone tetraiodothyronine (T-4). Thyroid hormones are responsible for regulating the metabolic rate in the body, and play a vital role in the absorption of proteins, fats and carbohydrates. 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