As a member of the selective serotonin reuptake inhibitor (SSRI) family, dapoxetine was initially created as an antidepressant. However, unlike other SSRIs, dapoxetine is absorbed and eliminated rapidly in the body. Its fast acting property makes it suitable for the treatment of PE but not as an antidepressant. Originally created by Eli Lilly pharmaceutical company, dapoxetine was sold to Johnson & Johnson in 2003 and submitted as a New Drug Application to the Food and Drug Administration (FDA) for the treatment of PE in 2004. Different dosage has different impacts on different types of PE. Dapoxetine 60 mg significantly improves the mean intravaginal ejaculation latency time (IELT) compared to that of dapoxetine 30 mg in men with lifelong PE, but there is no difference in men with acquired PE. Dapoxetine, given 1–3 hours before sexual episode, prolongs IELT and increases the sense of control and sexual satisfaction in men of 18 to 64 years of age with PE. 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It also has 510K clearance from the U. S. Food and Drug Administration. Dapoxetine is prescribed for the treatment of premature ejaculation. The most common side-effects include feeling dizzy or faint, and feeling sick. Drinking a full glass of water at the same time as taking the tablet can reduce these effects. Premature ejaculation is the term used when a man comes (ejaculates) more quickly than he and/or his partner would like. For some men it can be temporary and can get better on its own; for others, prescribed treatments such as dapoxetine tablets can be helpful. Dapoxetine is a selective serotonin reuptake inhibitor medicine which has specially been developed for the treatment of premature ejaculation. It increases the time it takes to ejaculate and can improve the control over the ejaculation. It starts to work very quickly, so it is taken when you anticipate having sex, rather than every day. Some medicines are not suitable for people with certain conditions, and sometimes a medicine can only be used if extra care is taken. Dapoxetine has been submitted for FDA approval and been denied on more than one occasion. Dapoxetine (INN, brand name Priligy) is a short-acting SSRI drug for the treatment of premature ejaculation in men. Dapoxetine is the only drug with regulatory approval for such treatment. Currently, it is approved for use in a handful of European countries including Finland, Sweden, Portugal, Austria and Germany. Dapoxetine is also being considered for approval in other European countries and in the United States where it is currently in Phase III of the Food and Drug Administration (FDA) approval process. On December 28, 2004, dapoxetine was submitted to the FDA in the form of dapoxetine hydrochloride by the ALZA Corporation and its parent company, Johnson & Johnson, for the treatment of premature ejaculation with a New Drug Application. 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