This content has not been reviewed within the past year and may not represent Web MD's most up-to-date information. To find the most current information, please enter your topic of interest into our search box. " March 16, 2000 (New York) -- In two head-to-head comparison studies, people with major depression treated with Effexor (venlafaxine) were more likely to recover completely than those treated with either Prozac (fluoxetine) or Zoloft (sertraline). "These findings are important because up until [now], there's been a general feeling that antidepressant drugs are all equal in [effectiveness]," says lead author of the Prozac investigation Richard L. "In the last few years, there's been mounting evidence that this may not be entirely true, particularly when you look at [recovery rates]." Researchers are starting to see evidence that certain classes of drugs, particularly those that act on two brain chemicals, may be better than those antidepressants that act on just one, Rudolph tells Web MD. Rudolph is senior director of clinical research and development at Wyeth-Ayerst Research, which supported both studies. There are multiple ways in which antidepressants work, explains Richard Shelton, MD, of the psychiatry department of Vanderbilt University in Nashville, Tenn. Older medicines like the tricyclic group act by influencing two important chemicals in the brain thought to contribute to mood control: norepinephrine and serotonin. "These medicines are very effective in reducing symptoms of depression, but have many other side effect problems," he says. I've been to hell and back when it comes to depression medications. I've been from through Celexa, Paxil, an antipsycotic called Perphenazine, Lithium, Currently take Wellbutrin and Clonezepam and I"m about at the end of my rope. Every SSRI that I took made me totally impotent and at the age of 25 I'm not willing to give up my sex drive without a fight. I fear that I have to accept that SSRIs are the medications that I respond best to. My doctor has mentioned Zoloft to me and said that it isn't sedating like Paxil and maybe with the help of Wellbutrin I can keep my sex drive. Literally, like while I was driving falling asleep. I feel like I'm at the end of my rope and I just have to know about this medication from someone who's been on it and through the symptoms and withdrawals. For some reason Wellbutrin seems to make me very easily agitated and doesn't seem to put my emotions in check as well as Paxil did but, Wellbutrin seems to give me more energy and doesn't kill my sex drive at all. I've also heard that Prozac might be a good option because it isn't sedating. I felt better for a while and I feel like I'm chasing that feeling that I had but, I just don't know where to go from here. I'm sorry to be rambling but, I just feel like I'm going to jump out of my own skin! Zoloft is considered a soft SSRI while Paxil is considered a potent SSRI. Can anyone give me any advise on these two medications before I call my doctor and accept one of them witch will most likely be Zoloft since that's the one that she's been leading towards. I had glimpses of normality and now I feel like I'm right back where I started. Zoloft is not linked with weight gain in the literature but everyone can react differently. I can't take another SSRI that puts me to sleep and I can't keep taking Wellbutrin by it's self because I feel like it's making me really mean. Prozac is a good SSRI too with stimulating proprieties. Cheap levitra uk Will xanax kill you You might want to read "Talking Back To Prozac" "Prozac Nation", and do a Google search on Prozac and it's side effects. There are horrible side effects such as not eating, paranoia, lack of sex drive, can't sleep, anxiety attacks, thoughts of suicide, homocide, ect. Zoloft Sertraline and Prozac Fluoxetine both belong to the SSRI Selective Serotonin Reuptake Inhibitors group of antidepressants. The effect and working of most SSRI is fairly similar, but individual chemical composition of each drug determines which works best for This mom describes her son's journey through Zoloft, Prozac and psychiatric care to finding Daily Essential Nutrients and recovery. NutraTalk. Prozac (fluoxetine) is a selective serotonin reuptake inhibitor (SSRI) antidepressant. Fluoxetine affects chemicals in the brain that may be unbalanced in people with depression, panic, anxiety, or obsessive-compulsive symptoms. Prozac is used to treat major depressive disorder, bulimia nervosa (an eating disorder), obsessive-compulsive disorder, and panic disorder. Prozac is sometimes used together with another medication called olanzapine (Zyprexa) to treat manic depression caused by bipolar disorder. This combination is also used to treat depression after at least 2 other medications have been tried without successful treatment of symptoms. If you also take olanzapine (Zyprexa), read the Zyprexa medication guide and all patient warnings and instructions provided with that medication. Prozac may also be used for purposes not listed in this medication guide. I was just reading the article on switching from one antidepressant to another. There is no single recommended way to switch antidepressants, and there are a variety of methods that can utilized. My doctor is trying to wean me off Zoloft (sertraline) but instead of taking me slowly down, she switched me to Prozac at a lower dose. Why didn't she just lower the sertraline little by little to wean me off of it? My primary care physician is the one doing all this. Before we discuss the two most common methods for switching from one SSRI (selective serotonin re-uptake inhibitor) to another, I want to point out that many patients do find that switching between different drugs in the same class (from Zoloft to Prozac in this example) can be effective. Can you help so I can tell her what I would rather do? Studies have shown that most individuals are equally as likely to respond to another drug in the same class as switching to another class. Some practitioners recommend a "cross-taper" method, which is most likely what you read in one of our other articles. With a cross-taper method, one SSRI is slowly decreased, while at the same time, starting at a low dose and gradually increasing the new SSRI. Some sources recommend a "cross-taper" when switching between different classes of antidepressants, to avoid withdrawal symptoms and symptom re-occurrence. Zoloft or prozac Prozac Backlash Overcoming the Dangers of Prozac, Zoloft, Paxil., Prozac vs Zoloft - Difference and Comparison Diffen Propecia wirkungDoxycycline side effects in men Victoria Toline needed nine months to taper off Zoloft. said in a statement the company “remains committed to Prozac and Cymbalta and. Many People Taking Antidepressants Discover They Cannot Quit.. My Son's Journey From Zoloft and Prozac to. - Hardy Nutritionals. Swich prozac to zoloft? -. Prozac fluoxetine is a selective serotonin reuptake inhibitor SSRI antidepressant. Fluoxetine affects chemicals in the brain that may be unbalanced in people with depression, panic, anxiety, or obsessive-compulsive symptoms. Both of these medications are SSRIs and increase the levels of serotonin in the brain which has been proven to treat depression. Taking both of these drugs. Prozac fluoxetine is a selective serotonin reuptake inhibitor SSRI and is most commonly used for the treatment of depression. It is also used to treat anxiety and panic disorders.