B, Brown pigmentation on the legs in another patient who had systemic lupus erythematosus associated with diffuse discoid lupus. The skin biopsy was performed on the brown area distant from discoid lesions. Can plaquenil cause bruising What drug is comparable to plaquenil Chloroquine diphosphate intercalator dna Hydroxychloroquine off label uses Some drugs can induce hair colour changes such as darkening of the original hair colour or repigmentation of grey hair in older people, lightening/bleaching from black or brown to blond hair, greying, reddening or even a complete colour change. These changes can affect scalp, eyelashes, eyebrows, moustaches or all body hair. Nail changes a dermatologist should examine. Have you noticed a change to any of your nails lately? A change in color, texture, or shape can be harmless, but it can also be a sign of disease. If you notice any of the following changes to a fingernail or toenail, it’s time to see a board-certified dermatologist. RARE side effects. If experienced, these tend to have a Severe expression. Abnormal Liver Function Tests. Acute Liver Failure. Acute Pustular Eruptions On Skin. Bronchospasm. Decreased Blood Platelets. Decreased White Blood Cells. B, Presence of iron in the same areas of the dermis (Perls staining, original magnification ×100). Pub Med Google Scholar Crossref Morrison LK, Nordlund JJ, Heffernan MP. Pub Med Google Scholar Costedoat-Chalumeau N, Galicier L, Aumaître O, et al; Group PLUS. Google Scholar Costedoat-Chalumeau N, Amoura Z, Hulot JS, et al. Pub Med Google Scholar Crossref Costedoat-Chalumeau N, Leroux G, Piette J-C, Amoura Z. A, Interstitial and perivascular brown pigmented granules in the dermis (hematoxylin-eosin-safran staining, original magnification ×100). Plaquenil nail changes Hydroxychloroquine and skin darkening Hi All. - LUPUS UK, Nail changes a dermatologist should examine Effects of hydroxychloroquine on tastePlaquenil maculopathy oct of maculaPlaquenil side effects stomach painChloroquine autophagy p62Alternatives to plaquenil for rheumatoid arthritis Find patient medical information for Plaquenil Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Plaquenil Oral Uses, Side Effects, Interactions.. Common and Rare Side Effects for Plaquenil Oral. Skin Discoloration and Plaquenil - Arthritis Information. Brittle nails are characterized by hardness, peeling, crumbling, fissures, excess longitudinal ridges or lack of flexibility of the finger and toe nails. This sometimes causes pain and interferes with normal daily activities. Some changes in your nails are due to medical conditions that need attention. See your doctor if you have any of these symptoms discoloration dark streaks, white streaks, or changes in nail color Drug-induced nail disease is diagnosed when a medication affects nail growth or structure. Drugs may cause Changes to the shape of the nail nail deformity Changes in the texture or composition of the nail nail dystrophy Abnormality of the tissues around the nail paronychia Pigmentation of the nail plate.