Plaquenil and genetic marker

Discussion in 'Hydroxychloroquine' started by max_m, 22-Feb-2020.

  1. v_roger XenForo Moderator

    Plaquenil and genetic marker


    Mutations in HLA genes seem to play a crucial role in the pathogenesis of some cases (but not all), likewise silica, aromatic and chlorinated solvents, ketones, trichloroethylene, welding fumes and white spirits exposure seems to contribute to the condition in a small proportion of affected persons. Vitamin D is implicated in the pathophysiology of the disease.

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    Nov. 10, 2006 -- New research on the genetic roots of lupus may eventually lead to a blood test to help diagnose the disease. Lupus is an autoimmune disease in which the immune system mistakes. The genetic marker is a known DNA sequence or gene located on the chromosome which can be applied in the identification of individual species or organism or we can use it in the identification of other genes or DNA sequences. Before that let me give you a brief idea about how different genetic markers are developed. Genetic markers can help link an inherited disease with the responsible gene. DNA segments close to each other on a chromosome tend to be inherited together. Genetic markers are used to track the inheritance of a nearby gene that has not yet been identified, but whose approximate location is known.

    Typical scleroderma is classically defined as symmetrical skin thickening, with about 70% of cases also presenting with Raynaud's phenomenon, nail-fold capillary changes and antinuclear antibodies. An inverse correlation between plasma levels of vitamin D and scleroderma severity has been noted and vitamin D is known to play a crucial role in regulating (usually suppressing) the actions of the immune system.

    Plaquenil and genetic marker

    Many new genetic markers for lupus identified in large multi-ethnic., Different Type Of Genetic Markers

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  4. Thereare also color blindness patients that never inherited the condition, but whoseproblem is associated with the use of some medications such as Plaquenil rheumatoidarthritis drug after birth. As many genetic conditions color vision deficiency is linkedto the gene present on X chromosome and because of that it is known as the Xlinked.

    • Color blindness genetics General center.
    • Genetic Marker Talking Glossary of Genetic Terms NHGRI.
    • Ehlers-Danlos syndrome - Diagnosis and treatment - Mayo Clinic.

    The results tell of genetic markers that, if present, may signal susceptibilities to certain health conditions. These markers, called SNPs or single nucleotide polymorphisms, are variations in. Systemic lupus erythematosus “SLE” or “lupus” can be overwhelming and mysterious at times. In this video series, Dr. Stojan of the Johns Hopkins Lupus Center shares an overview of this disease, signs and symptoms, diagnosis, treatment and lifestyle considerations. Supporting the theory that genetic makeup is a risk factor, about 50% of people with reactive arthritis carry a gene called HLA-B27, compared with 8% of the general population. Reactive arthritis is thought to be an autoimmune disorder, which means the body's immune system mistakenly attacks its own tissues.

     
  5. juvent XenForo Moderator

    Summary Chloroquine is an anti-malarial drug available at pharmacies for people traveling to area with malaria risks. Hydroxychloroquine - Memorial Sloan Kettering Cancer Center Hydroxychloroquine Plaquenil Success, Reviews and Side Effects Hydroxychloroquine Skin Support
     
  6. goldensp New Member

    What can Hydroxychloroquine Plaquenil do to my eyes? Jan 18, 2019 The recommendation is to have a baseline eye exam with dilation and a visual field test before or soon after starting the drug. A repeat of that exam should occur every year IF there is no evidence of toxicity.

    Eye screening for patients taking hydroxychloroquine Plaquenil