Begin 1-2 days before travel, daily during travel, and for 7 days after leaving. 1250 mg orally as a single dose Use: For treatment of mild to moderate acute malaria due to mefloquine-susceptible strains of Plasmodium falciparum (both chloroquine-susceptible and -resistant strains) or P vivax US CDC Recommendations: 750 mg orally as initial dose, followed by 500 mg orally 6 to 12 hours after initial dose Comments: -Recommended for treatment of uncomplicated malaria due to chloroquine-resistant (or unknown resistance) P falciparum (or species not identified) if other preferred regimens cannot be used; not recommended if infection was acquired in Southeast Asia (due to resistance) -With (primaquine or tafenoquine [Krintafel]), recommended for treatment of uncomplicated malaria due to chloroquine-resistant P vivax; this drug should be used alone during pregnancy. Plaquenil cause muscle pain Metabolic fate of chloroquine Chloroquine syrup dosage Mefloquine, like chloroquine and quinine, is a blood schizonticidal agent and is active against the intraerythrocytic stages of parasite development. Similar to chloroquine and quinine, mefloquine appears to interfere with the parasite's ability to metabolize and utilize erythrocyte hemoglobin. Mefloquine is a useful alternative treatment for P. vivax malaria and P. falciparum malaria in areas such as Papua, where chloroquine is still recommended as the first-line therapeutic agent. Compare Mefloquine vs. Plaquenil Head-to-head comparisons of medication uses, side effects, ratings, and more. ADVERTISEMENT. Lariam. Plaquenil hydroxychloroquine. The Lariam Mefloquine FDA package insert doesn’t have numbers about how common side effects are. 250 mg orally once a week Comments: -This drug should be taken on the same day of each week, preferably after the main meal. -After IV artesunate, for severe malaria (if other options are not available); if needed, as interim therapy for severe malaria until IV artesunate arrives (if other options are not available) -Current guidelines should be consulted for additional information. Mefloquine lariam and chloroquine CDC - Malaria - Update New Recommendations for Mefloquine., Mefloquine Is Highly Efficacious against Chloroquine. Does hydroxychloroquine sulfate make you tiredChloroquine in treatment of hypercalcemiaSuicidal chloroquine poisoningCan you just stop taking plaquenilPlaquenil and methotrexate together Mefloquine previously marketed in the United States as Lariam® is an antimalarial medication with potent psychotropic potential. Severe psychiatric side effects due to mefloquine intoxication are well documented, including anxiety, panic attacks, paranoia, persecutory delusions, dissociative psychosis, and anterograde amnesia. Exposure to the drug has been associated with acts of violence. Psychiatric Side Effects of Mefloquine Applications to.. Compare Mefloquine vs Plaquenil -. LARIAM brand of mefloquine hydrochloride TABLETS R. Mefloquine is a medicine used to treat malaria, a disease caused by parasites. This medicine works by interfering with the growth of parasites in the red blood cells of the human body. The chloroquine FDA package insert doesn’t have numbers about how common side effects are. The Lariam Mefloquine FDA package insert doesn’t have numbers about how common side effects are. Risks and risk factors Drug interactions Taking mefloquine at the same time as other medications, including quinine, quinidine, and chloroquine, may cause heart rhythm problems, cardiac arrest, or increase the risk of seizures. Do not take these medications at the same time as mefloquine.