Chloroquine heme polymerase

Discussion in 'Hydroxychloroquine' started by T-{[email protected]}, 05-Mar-2020.

  1. mottoman XenForo Moderator

    Chloroquine heme polymerase


    These hematophagous organisms such as Malaria parasites (Plasmodium spp.), Rhodnius and Schistosoma digest haemoglobin and release high quantities of free heme, which is the non-protein component of hemoglobin. Heme is a prosthetic group consisting of an iron atom contained in the center of a heterocyclic porphyrin ring.

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    A 4-aminoquinoline with antimalarial, anti-inflammatory, and potential chemosensitization and radiosensitization activities. Although the mechanism is not well understood, chloroquine is shown to inhibit the parasitic enzyme heme polymerase that converts the toxic heme into non-toxic hemazoin, thereby resulting in the accumulation of toxic heme within the parasite. Chloroquine phosphate is a 4-aminoquinolone that acts by inhibiting heme polymerase. 198 Chloroquine is well tolerated and in appropriate doses may be safely used by young children and pregnant women. 199 Transient nausea or vomiting is seen in a small proportion of individuals and may usually be reduced by taking the drug with food. It has high affinity for chloroquine, which is another mechanism for trapping chloroquine. Once trapped, chloroquine acts by one of many ways a. Inactivation of heme-polymerase responsible for conversion of heme part of hemoglobin into hemozoin. Conversion does not take place, heme is toxic to plasmodium, resulting in death of plasmodium. b.

    In malaria parasites, hemozoin is often called malaria pigment. Free heme is toxic to cells, so the parasites convert it into an insoluble crystalline form called hemozoin.

    Chloroquine heme polymerase

    Chloroquine diphosphate ≥99%HPLC Selleck ATM/ATR., Chloroquine - an overview ScienceDirect Topics

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    Heme is a prosthetic group consisting of an iron atom contained in the center of a heterocyclic porphyrin ring. Free heme is toxic to cells, so the parasites convert it into an insoluble crystalline form called hemozoin. In malaria parasites, hemozoin is often called malaria pigment. A heme polymerase is described. The polymerase is critical in the biology of malaria. By using this novel polymerase, assays useful in developing anti-malaria drugs are made possible. Beyond providing a key for future drug studies and biochemical characterizations, treatments for malaria including quinoline-resistant malarias are made possible. Chloroquine is the most widely used drug against malaria, except for those cases caused by chloroquine resistant Plasmodium falciparum. Although the mechanism of action is not fully understood, chloroquine is shown to inhibit the parasitic enzyme heme polymerase that converts the toxic heme into non-toxic hemazoin, thereby resulting in the.

     
  5. svarovski Well-Known Member

    Hydroxychloroquine is used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses Plaquenil Hydroxychloroquine Uses, Dosage, Side Effects. Plaquenil hydroxychloroquine Basics, Side Effects & Reviews.
     
  6. din Well-Known Member

    Plaquenil (hydroxychloroquine) belongs to a group of medicines called quinolines. Hydroxychloroquine Memorial Sloan Kettering Cancer Center Hydroxychloroquine Plaquenil and Cancer Is there an. Chloroquine & Hydroxychloroquine supporting chemo.
     
  7. toomai User

    How Effective is Hydroxychloroquine, Know It’s Dosage, Side Effects Hydroxychloroquine is a type of quinoline drug for effective prevention or treatment malaria. Malaria is originated by parasites which come into the body via mosquito bite. This disease is most common in South America, south Asia and in Africa. However hydroxychloroquine will not treat all types of malaria.

    Hydroxychloroquine - Side Effects, Dosage, Interactions.
     
  8. musariev Moderator

    RA and Hydroxychloroquine How Effective is it for Rheumatoid. What Conditions Does This Treat? Originally, hydroxychloroquine was used to prevent and treat malaria and was considered very effective. Now it is generally used for rheumatoid arthritis, but it has also been shown to work well for juvenile arthritis, some lupus symptoms, and other types of autoimmune conditions.

    Hydroxychloroquine - Wikipedia