I did stop it for 2 weeks early in the treatment due to having to take a coupld other drugs that seemed to give me side effects. I just quit the plaquenil to give my liver a rest at that time. Plaquenil isn a antiparasitic drug with anti-inflammatory affect. Hydroxychloroquine-mediated retinopathy Chloroquin toxicity Plaquenil macular changes Can you take phenylephrine with plaquenil Find patient medical information for Plaquenil Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Plaquenil is generally well-tolerated, but side effects are possible. Common side effects linked to Plaquenil include nausea and diarrhea. Taking the medication with food eases nausea for most people taking the drug. Less common side effects include skin rashes, hair thinning, and weakness. Along with its needed effects, hydroxychloroquine the active ingredient contained in Plaquenil may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine Over the years on this site we have had quite a few people post that they didn't think that the plaquenil was working so they would stop taking it. I have done a lot of research on this drug and haven't run into anybody who has complained of the withdrawal effect. Plaquenil side effects when stopping Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses, Taking Plaquenil for Rheumatoid Arthritis Icd 10 plaquenilPlaquenil bradycardiaIs plaquenil an immunosuppressantHydroxychloroquine for sjogren's syndrome These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about. Hydroxychloroquine Oral Route Side Effects - Mayo Clinic. Plaquenil Side Effects Common, Severe, Long Term -. Let me tell you what weaning down from Plaquenil is like.. Like I have pressure on the top of my head. I nver had this before. Could this be a side effect of the Plaquenil and does it normaly go away after I take it for a while? Answer. That is an unusual side effect for Plaquenil. I would try stopping and restarting it to make sure Plaquenil is at fault. Plaquenil is the brand name of hydroxychloroquine, a drug used to prevent or treat malaria. Plaquenil can cause serious side effects when used in high doses for chronic diseases such as RA over the long term. Hello all, I am currently new to this site and ran across the discussion about stopping Plaquenil. I have been taking Plaquenil for about 8-9 months and thought that it was not helping me because I still have a fair amount of joint pain, fatigue, muscle pain and so many other issues.