While these reviews might be helpful, they are not a substitute for the expertise, skill, knowledge and judgement of healthcare practitioners. "I started the hydroxychloroquine medication a week ago and within the first day or two noticed a big difference in my pain and fatigue with major improvement SLE. Plaquenil make nails brittle Cutaneous hyperpigmentation during therapy with hydroxychloroquine I have UCTD and Fibromyalgia. My Rheum. has me on prednisone 10 mg and plaquenil 400 mg. I have only been taking the plaquenil for three weeks. Still have alot of fatigue and have been in a mini flare with fever, rash, mouth sores, weakness and joint pains the past few days. 8 replies Hi. Been taking plaquenil for 2 weeks. About 10 days ago I came up with a rash on back of my hands. V itchy similar to nettle rashesp at night and in sun. Was unsure whether it was connected to plaquenil or possibly sun as it was a sunny day when it came up. I have had lupus for 13 years. It took 4 years to diagnose it. My blood tests did not show the normal results for a positive lupus test but the doctor said let's try you on Plaquenil. I responded to the Plaquenil so we decided I have lupus. I was doing fine with no flare ups until last March when I was hospitalized for pain management. I have been getting these horrible rashes and they are not related to sun exposure. I am interested to see if anyone here has gotten a rash from Plaquenil after being on it for several months. Plaquenil for lupus rash Terrible Itching on Plaquenil---PLEASE HELP., Plaquenil rash or something else? Lupus Forums at The Lupus. Plaquenil maculopathy fluorescence angiographyPlaquenil 100 mgNumber needed to treat hydroxychloroquineMalaria drug combined mice chloroquine 17 2019Can i dissolve hydroxychloroquine tablets in water Lupus can be difficult to diagnose because its signs and symptoms often mimic those of other ailments. The most distinctive sign of lupus — a facial rash that resembles the wings of a butterfly unfolding across both cheeks — occurs in many but not all cases of lupus. Lupus - Symptoms and causes - Mayo Clinic. Lupus Symptoms and Signs Diagnosis, Treatment, Causes.. Hydroxychloroquine - Wikipedia. I have actually had this same reoccurring rash for about 5 years, but wasn't diagnosed with lupus until earlier this year. So mine is def not caused by the Plaquenil. My doc cannot find the connection, but the only thing that helps me is Zyrtec I use the generic. I hope this at least helps you find relief with the rash. It does not appear to be from the Plaquenil but, simply Lupus. Don't mean to scare you but, this can be caused by Plaquenil OR by Lupus OR M. S. Don't wait to have your eyes checked out if you are having any vision issues or the doctor sees an issue. Hydroxychloroquine Plaquenil is a drug that is classified as an anti-malarial drug. Plaquenil is prescribed for the treatment or prevention of malaria. It is also prescribed for the treatment of rheumatoid arthritis, lupus, and the side effects of lupus such as hair loss, joint pain, and more.