Malaria is common in areas such as Africa, South America, and Southern Asia. This medicine is not effective against all strains of malaria. Chloroquine qt prolongation Wallace 1989 chloroquine One Plaquenil tablet contains 200 mg of hydroxychloroquine sulfate, which is equivalent to 155 mg base. Take Plaquenil with a meal or a glass of milk. Malaria. Prophylaxis Adults 400 mg 310 mg base once weekly on the same day of each week starting 2 weeks prior to exposure, and continued for 4 weeks after leaving the endemic area. The recommended initial dosage of hydroxychloroquine Plaquenil for the treatment of lupus erythematosus is 400 mg once or twice daily. The recommended maintenance dose range of hydroxychloroquine Plaquenil for the treatment of lupus erythematosus is 200 to 400 mg daily. Initial dose 400 mg 310 mg base orally once or twice a day for several weeks or months, depending on patient response Maintenance dose 200 to 400 mg 155 to 310 mg base orally once a day Each dose should be taken with a meal or a glass of milk. Taking hydroxychloroquine long-term or at high doses may cause irreversible damage to the retina of your eye. Hydroxychloroquine is also an antirheumatic medicine and is used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. Plaquenil 400 mg once a day What can Hydroxychloroquine Plaquenil do to my eyes?, Plaquenil - Side Effects, Uses, Dosage, Overdose. Hydroxychloroquine sulfate vs chloroquineHydroxychloroquine overdose side effectsPlaquenil muscle toxicityPlaquenil bruising I started on 400 mg 200 mg twice a day when I was in a flare maybe 7 or so years ago. Once I tapered off all the other meds and was what my docs all considered stable, I dropped to 200mg once a day. Going from 400 to 200 in plaquenil? lupus - reddit. Hydroxychloroquine Uses, Dosage & Side Effects -. Hydroxychloroquine Oral Uses, Side Effects, Interactions.. I think you can take it all at once if it doesnt cause you to feel sick. Though my rheumies instructions were 1 200mg twice a day. Also, the therapeutic dose for plaquenil is 400mg daily. For prevention of malaria Adults— Standard dosing 400 mg once a week on the same day of each week starting 2 weeks before traveling to an area where malaria occurs, and continued for 4 weeks after leaving the area. Weight-based dosing Dose is based on body weight and must be determined by your doctor. Plaquenil Dosage for Malaria Treatment. For adults, the recommended dose for malaria treatment is 800 mg for the first dose, followed by 400 mg for the second dose six to eight hours later, then followed by 400 mg per day for the next two days. Alternatively, a single 800 mg dose may also be effective.