Erythromycin alcoholic solution contains the active ingredient erythromycin, which is a type of medicine known as a macrolide antibiotic. It interferes with bacterial protein synthesis by binding to the 50S subunit of ribosomes of sensitive organisms. Erythromycin solution is applied to the skin to treat acne. The erythromycin works by attacking the bacteria associated with acne, Propionibacterium acnes. This is a common type of bacteria that feeds on sebum produced by the sebaceous glands in the skin. Although the mechanism of action of Erythromycin in reducing inflammatory lesions of acne vulgaris has not been conclusively shown, it is presumably due to its antibiotic action on sensitive bacteria, and in reducing follicular porphyrin fluorescence and free fatty acid levels of skin lipids. Erythromycin prevens these bacteria from producing proteins that are essential to them. Without these proteins the bacteria cannot grow, replicate and increase in numbers. 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