Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Patient information leaflet on hydroxychloroquine Side effects of quitting plaquenil Chloroquine vs quinine Chloroquine resistance in china Note This document contains side effect information about hydroxychloroquine. Some of the dosage forms listed on this page may not apply to the brand name Plaquenil. For the Consumer. Applies to hydroxychloroquine oral tablet. Along with its needed effects, hydroxychloroquine the active ingredient contained in Plaquenil may cause some unwanted effects. Stevens-Johnson syndrome SJS is a rare and serious condition of your skin and mucus membranes. SJS will cause you to lose up to 10% of your outer layer of skin. SJS is usually caused by a response to a medicine you have been taking. Stevens-Johnson syndrome erythema multiforme is an acute inflammatory polymorphic disease affecting skin and mucous membranes. All ages may be affected, and the incidence is equal in both sexes. This is a severe disease with a 5%–15% mortality rate. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Plaquenil steven johnson syndrome Stevens–Johnson syndrome in association with., Stevens-Johnson Syndrome - What You Need to Know Mechanism of action of chloroquine pdf Stevens-Johnson syndrome requires hospitalization, often in an intensive care unit or a burn unit. Stopping nonessential medications The first and most important step in treating Stevens-Johnson syndrome is to discontinue any medications that may be causing it. Stevens-Johnson syndrome - Diagnosis and treatment - Mayo Clinic. Stevens-Johnson Syndrome. Fact Sheet Stevens Johnson Syndrome by Mayo Clinic HealthShare. Stevens-Johnson syndrome was named after two American pediatricians in 1922, Albert Stevens and Frank Johnson. They made a published description of the disorder in an American journal about two boys who had generalized skin eruptions with continuous fever, severe purulent conjunctivitis and inflamed oral mucosa. Very rarely, Stevens-Johnson syndrome/toxic epidermal necrolysis can occur. Very rarely, the skin and mucosa can change to a black-blue colour in a process called dyschromia. Hydroxychloroquine can also exacerbate psoriasis. In patients with glucose-6-phosphate deficiency, hemolysis can occur. The adult dose of Plaquenil to treat an acute attack of malaria is an initial dose of 800 mg followed by 400 mg in six to eight hours and 400 mg for two more days. To treat lupus erythematosus, the average adult dose is 400 mg once or twice daily.