Note: based on a RGCC chemosensitivity analysis I have seen at a German clinic, Hydroxychloroquine has been effective in killing the cancer cells of 5 out 7 patients that were tested. It is one of very few available drugs that inhibits autophagy, a mechanism associated with its anticancer properties. Half life of hydroxychloroquine Bonine and plaquenil interaction Feb 26, 2020 Previous findings supported by the TSCRP suggested that mutated TSC1 and TSC2 suppress autophagy, allowing mutated cells to proliferate. In vitro studies found that administration of autophagy inhibitor hydroxychloroquine in combination with Sirolimus decreased survival of TSC2 deficient cells, and reduced the tumor size in mouse models. Up to 50% of tumors will acquire resistance to these interventions. Autophagy has been implicated as a major driver of antiestrogen resistance. We have explored the ability of hydroxychloroquine HCQ, which inhibits autophagy, to affect antiestrogen responsiveness. Hydroxychloroquine HCQ is a potent autophagy inhibitor and TLR9 inhibitor. It prevents lysosomal acidification, thereby interfering with a key step in the autophagic process. In cancer cells, HCQ treatment has been shown to cause increased apoptosis, tumor regression, and delay in tumor recurrence. In cancer, authophagy is the process used by cancer cells to “self-eat” in order to survive. Specifically, if authophagy is prolonged this will become a lethal process to cancer. duing chemotheraphy, radiotheraphy, etc.) authophagy is used by cancer cells to survive. However, note that Chloroquine has other properties as well that may be very well related to anti cancer mechanism, such as zinc ionophore, and others (see below the section on mechanisms). Hydroxychloroquine autophagy inhibitor Targeting Autophagy in Cancer Update on Clinical Trials and., Hydroxychloroquine inhibits autophagy to potentiate. Plaquenil sun spotsChloroquine treatsP62 chloroquine Hydroxychloroquine can be combined with other agents in renal or other solid cancers to augment autophagy inhibition as an anti-cancer mechanism. Abstract. Purpose. Everolimus inhibits the mechanistic target of rapamycin mTOR, activating cytoprotective autophagy. Hydroxychloroquine HCQ inhibits autophagy. Based on Autophagy inhibition to augment mTOR inhibition A phase I/II.. Hydroxychloroquine HCQ, Autophagy and TLR9 Inhibitor.. Research progress of hydroxychloroquine and autophagy.. Rangwala, R. et al. Combined MTOR and autophagy inhibition phase I trial of hydroxychloroquine and temsirolimus in patients with advanced solid tumors and melanoma. Autophagy 10, 1391–1402 2014. Autophagy inhibition remains a very attractive strategy to augment standard therapy and improve long-term outcomes for a broad range of malignancies. Our collective work, to date, has demonstrated that we are finally on a strategic trajectory to move beyond HCQ with respect to clinical autophagy inhibition. One mechanism that may alter anoikis is autophagy. Using an autophagic flux inhibitor hydroxychloroquine HCQ, we identified that it reduces the in vitro survival capacity of human endometriotic.