Deschloroquine used on chloroquine resistant parasites

Discussion in 'Canadian Pharmacy Online' started by Cassandra, 27-Feb-2020.

  1. Genek12 New Member

    Deschloroquine used on chloroquine resistant parasites


    Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it.

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    Plasmodium falciparum chloroquine resistance is a major cause of worldwide increases in malaria mortality and morbidity. Recent laboratory and clinical studies have associated chloroquine resistance with point mutations in the gene pfcrt. However, direct proof of a causal relationship has remained elusive and most models have posited a multigenic basis of resistance. Here, we provide. Plasmodium falciparum chloroquine resistance is a major cause of worldwide increases in malaria mortality and morbidity. Recent laboratory and clinical studies have associated chloroquine resistance with point mutations in the gene pfcrt. However, direct proof of a causal relationship has remained elusive and most models have posited a. P. vivax resistance to chloroquine has also now been identified in Southeast Asia, Ethiopia, and Madagascar. Isolated reports have suggested chloroquine-resistance P. vivax in other countries and regions, but further evaluation is needed. Vivax malaria parasites, particularly from Oceania.

    The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead.

    Deschloroquine used on chloroquine resistant parasites

    The pH of the digestive vacuole of Plasmodium falciparum is., Chloroquine Resistance in Plasmodium falciparum Malaria Parasites.

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  5. Verapamil Reversal of Chloroquine Resistance in the Malaria Parasite Plasmodium falciparum Is Specific for Resistant Parasites and Independent of the Weak Base Effect

    • PDF Verapamil Reversal of Chloroquine Resistance in the..
    • Drug Resistance in the Malaria-Endemic World - CDC.
    • On the Mechanism of Chloroquine Resistance in Plasmodium falciparum.

    Chloroquine has long been used in the treatment or prevention of malaria from Plasmodium vivax, P. ovale, and P. malariae, excluding the malaria parasite Plasmodium falciparum, for it started to develop widespread resistance to it. Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. Nov 27, 2019 Kim et al. used single-particle cryo-EM to determine the structure of PfCRT in South American 7G8 parasites, which harbour mutations that confer high-level chloroquine resistance. Chloroquine is used extensively in malaria endemic areas in Africa to treat the uncomplicated form of Plasmodium falciparum malaria. However, the efficiency of chloroquine has been severely impacted by the recent development of chloroquine resistant plasmodium falciparum parasites.

     
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