A team from the University of Rochester Medical Center has shown scientifically what many women report anecdotally: that the breast cancer drug tamoxifen is toxic to cells of the brain and central nervous system, producing mental fogginess similar to "chemo brain." A team from the University of Rochester Medical Center has shown scientifically what many women report anecdotally: that the breast cancer drug tamoxifen is toxic to cells of the brain and central nervous system, producing mental fogginess similar to "chemo brain." , researchers also report they've discovered an existing drug compound that appears to counteract or rescue brain cells from the adverse effects of the breast cancer drug. D., professor of Biomedical Genetics and director of the UR Stem Cell and Regenerative Medicine Institute, said it's exciting to potentially be able to prevent a toxic reaction to one of the oldest and most widely used breast cancer medications on the market. Although tamoxifen is relatively benign compared to most cancer treatments, it nonetheless produces troubling side effects in a subset of the large number of people who take it. By studying tamoxifen's impact on central nervous system cell populations and then screening a library of 1,040 compounds already in clinical use or clinical trials, his team identified a substance known as AZD6244, and showed that it essentially eliminated tamoxifen-induced killing of brain cells in mice. "As far as I know, no one else has discovered an agent that singles out and protects brain and central nervous system cells while also not protecting cancer cells," Noble said. "This creates a whole new paradigm; it's where we need to go." The research is the result of two separate but related projects from Noble's lab. One investigates the science underlying a condition known as "chemo brain," and another is looking at how to exploit tamoxifen's attributes for use in other types of cancer besides early-stage, less-aggressive breast cancer. (The drug is a type of hormonal therapy, which works by stopping the growth of estrogen-sensitive tumors.) In the paper, Noble's team first identified central nervous system (CNS) cells that are most vulnerable to tamoxifen toxicity. Tamoxifen blocks the actions of estrogen, a female hormone. Certain types of breast cancer require estrogen to grow. Tamoxifen is used to treat some types of breast cancer in men and women. It is also used to lower a woman's chance of developing breast cancer if she has a high risk (such as a family history of breast cancer). Use a barrier form of birth control (such as a condom or diaphragm with spermicide) while you are using this medication and for at least 2 months after your treatment ends. Tamoxifen may also be used for purposes not listed in this medication guide. You should not use tamoxifen if you are allergic to it, or if you have a history of blood clots in your veins or your lungs, or if you are also taking a blood thinner such as warfarin (Coumadin). Before using this medicine, tell your doctor if you have liver disease, high triglycerides (a type of fat in the blood), a history of cataract, or a history of stroke or blood clot. Also tell your doctor if you if you are receiving chemotherapy or radiation treatment. Tadalafil 20mg uk Diflucan pregnancy Doxycycline used to treat Lasix 10 mg Tamoxifen blocks the actions of estrogen, a female hormone. Certain types of breast cancer require estrogen to grow. Tamoxifen is used to treat some types of breast cancer in men and women. Mental fog with tamoxifen is real; possible antidote discovered Date September 17, 2013 Source University of Rochester Medical Center Summary A team from the University of Rochester Medical. Many women take anti-estrogen drugs like Tamoxifen and there are breast cancer treatment side effects to be aware of. One of which is brain fog. Learn more. Memory is your mind's ability to keep and remember information. You go to another room to get something, only you forget what you needed when you get there. Maybe you can't find your car keys one day and your glasses the next. These occasional memory lapses are normal signs that your brain is a little overworked. But memory loss also can be part of a bigger problem that's more serious than just misplaced car keys. If you answer “yes” to them, ask your doctor to evaluate your memory loss. There are other treatment side effects that can affect your memory, including trouble sleeping and fatigue. Memory loss also can be a side effect of other medicines, such as steroids, anti-depressants, sleeping pills, and pain medications. Talk to your doctor if you think a medication may be contributing to your memory loss. Your head feels foggy — you just called a child or friend by the dog’s name and the dog is wondering why it hasn’t been fed. As a woman with breast cancer, chances are you’ve heard of chemo brain but you’re not going through chemotherapy. Instead, your doctor has you on anti-estrogen medication. However, you have experienced tamoxifen side effects and have noticed a difference in your ability to focus, remember information, or keep track of everyday tasks. For women taking anti-estrogen drugs such as tamoxifen, these changes in cognitive function have been described as brain fog, a term used to describe mental confusion, forgetfulness or lack of mental clarity. For women on tamoxifen who experience these symptoms, it may be due to low estrogen levels, which can tamper with specific cells in your brain. The root of your problems may be due to your anti-estrogen therapy. 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