I had some of the usual problems with the upset stomach at the beginning but it got better with time. Over the last 8-10 weeks I have noticed that I have been getting very dark circles under my eyes which starts at the inner corner of my eye. Chloroquine base molecular weight Chloroquin rezeptfrei Nail Abnormalities Clues to Systemic Disease. Silver poisoning will turn the nail itself a blue-gray color. Excessive fluoride ingestion can turn nails brown or black. Nail abnormalities are common, affecting the shape, thickness, or color of the nails. In this article, we look at possible abnormalities that affect the fingernails or toenails, with a picture. I was diagnosed with Raynauds in 1998. I was told it was severe by a Vascular Surgeon. I don’t have spells, mine is constant my nails are gray and I have modeling on the upper parts on my fingers and my full toes. My skin around my toenails has had ulcers due to the Raynauds. I take Cialis daily to help with blood flow. I thought it was because I was not doing very well for a couple of weeks.... When I looked closer the skin is a little red with a bluish black color like a bruise. Gray nails and plaquenil Plaquenil Oral Uses, Side Effects, Interactions, Pictures, Warnings., Nail abnormalities Causes, symptoms, and pictures Plaquenil drug insert Skin pigmentation related to use of hydroxychloroquine starts out as a yellow brown to slate gray or black pigmentation on many areas of the body - especially the front of the shins but also the face, forearms, mouth mucosa essentially hard palace and gingivae and nail beds. How common is it? Skin Pigmentation with Hydroxychloroquine Plaquenil.. Raynaud's Disease and its Connection to Rheumatoid Arthritis. Nail Colors OPI®. Plaquenil can cause serious side effects when used in high doses for chronic diseases such as RA over the long term. The New Zealand Dermatological Society recommends that to decrease the risk of retina damage, no more than 200mg of Plaquenil should be taken a day, and a dose of 400mg per day should be taken no longer than a few weeks. Lichen planus LP is a disease of the skin and, less often, the scalp, fingernails, toenails, and/or inside the mouth or genitalia mucous membranes. Lichen planus can resolve on its own without treatment or be chronic, even with aggressive treatment. The cause of the inflammation that leads to lichen planus is unknown. Who's at risk? Hydroxychloroquine-induced pigmentation lesions usually begin after a few months or years of treatment. When we compared our patients with the controls, we found no significant association with the duration of HCQ treatment or with the cumulative dose of HCQ.