Chloroquine function in lysosome

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    Chloroquine function in lysosome


    Parasites that cause malaria typically enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia.

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    Inhibitory effect of chloroquine on bone resorp-. Key words chloroquine, lysosome, osteoclast, inflammatory bone disease. This study demonstrates the importance of the lysosome in the function as well as the differentiation of osteoclasts. Materials and methods 1Mice Lysosomal Function and Dysfunction Mechanism and Disease Patricia Boya Abstract Significance Lysosomes are organelles in which cellular degradation occurs in a controlled manner, separated from other cellular components. As several pathways terminate in the lysosome, lysosomal dysfunction has a Chloroquine is a lysosomotropic agent that prevents endosomal acidification 1. It accumulates inside the acidic parts of the cell, including endosomes and lysosomes. This accumulation leads to inhibition of lysosomal enzymes that require an acidic pH, and prevents fusion of endosomes and lysosomes.

    Chloroquine is also used to treat amebiasis (infection caused by amoebae). Chloroquine is used to treat and to prevent malaria.

    Chloroquine function in lysosome

    Lysosome Definition, Structure & Function Sciencing, Lysosomal Function and Dysfunction Mechanism and Disease

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  7. In this study, ARPE-19 cells were treated with chloroquine to inhibit lysosomal function. Chloroquine-treated ARPE-19 cells demonstrate a marked increase in vacuolation and dense intracellular debris. These are identified as chloroquine-dilated lysosomes and lipid bodies with LAMP-2 and LipidTOX co-localization, respectively.

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    When chloroquine enters the lysosome, it becomes protonated because of the low pH within the lysosome, and accumulation of the protonated form of chloroquine within the lysosome leads to less acidic conditions and, thereby, decreased lysosomal function. In addition to the well‐known functions of chloroquine such as elevations of endosomal pH, the drug appears to interfere with terminal glycosylation of the cellular receptor, ACE2. This may negatively affect the virus‐receptor binding and abrogate the infection. Chloroquine is an anti-malaria medicine that works by interfering with the growth of parasites in the red blood cells of the human body. Parasites that cause malaria typically enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia.

     
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    Generic Name: Atovaquone and Proguanil Hydrochloride Class: Antimalarials Chemical Name: trans-2-[4-(4-Chlorophenyl)cyclohexyl]-3-hydroxy-1,4-naphthalenedione CAS Number: 95233-18-4 Atovaquone and Proguanil Hydrochloride is also contained as an ingredient in the following combinations: Atovaquone and Proguanil Hydrochloride Medically reviewed by Risk of acquiring malaria varies substantially from traveler to traveler and from region to region (even within a single country) because of differences in intensity of malaria transmission within the various regions and season, itinerary, duration, and type of travel. Antimalarial drugs An overview - UpToDate Antimalarial Drug Resistance. - PubMed Central PMC CHLOROQUINE RESISTANCE IN MALARIA A DEFICIENCY OF CHLOROQUINE BINDING.
     
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    Hydroxychloroquine Retinopathy Still Alive and Well - The. May 16, 2011 Hydroxychloroquine Plaquenil; HCQ has been an important and effective drug for the treatment of lupus erythematosus and related autoimmune and inflammatory diseases for half a century, although its potential to cause retinal damage continues to raise concern among rheumatologists and ophthalmologists.

    Chloroquine Retinopathy - an overview ScienceDirect Topics