Chloroquine autophagy inhibitor

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  1. rescue Guest

    Chloroquine autophagy inhibitor


    Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it.

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    Chloroquine phosphate 50-63-5 is an antimalarial drug. Inhibits autophagy in a variety of cell lines 1. Induces cell death in breast cancer cell lines and displays antitumor and antimetastatic activity in mouse models of breast cancer 2. Eliminates cancer stem cells via deregulation of Jak2 and DNMT1 3. Inhibition of autophagy with either chloroquine or ATG5 short hairpin RNA shRNA enhanced the ability of either p53 activation or alkylating drug therapy to induce tumor cell death. These studies provide evidence that autophagy serves as a survival pathway in tumor cells treated with apoptosis activators and a rationale for the use of autophagy inhibitors such as chloroquine in combination with therapies designed to induce apoptosis in human cancers. Similar to bafilomycin, the former malaria drug chloroquine CQ is now widely used as an inhibitor of autophagy in both cell culture and in vivo. Chloroquine has a long history of human use and is currently being tested as a sensitizing agent for certain cancers, making understanding its mechanisms of action both topical and important 7, 8, 9.

    The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead.

    Chloroquine autophagy inhibitor

    What is the best applicable inhibitor of autophagy?, JCI - Autophagy inhibition enhances therapy-induced apoptosis in a Myc.

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  6. Chloroquine diphosphate, apoptosis and autophagy inhibitor CAS 50-63-5, with 98% purity. Water soluble compound. Join researchers using our high quality biochemicals.

    • Chloroquine diphosphate, apoptosis and autophagy inhibitor. - Abcam.
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    Jul 11, 2018 Chloroquine CQ, which is frequently used clinically as an antimalarial agent, is a classic inhibitor of autophagy that blocks the binding of autophagosomes to lysosomes by altering the acidic environment of lysosomes, resulting in the accumulation of a large number of degraded proteins in cells. Accordingly, we found that the autophagy inhibitor chloroquine and genetic or pharmacologic inhibition of specific autophagy regulators synergistically enhanced the ability of ERK inhibitors to mediate antitumor activity in KRAS-driven PDAC. We conclude that combinations of pharmacologic inhibitors that concurrently block both ERK MAPK. Autophagy has a pro-tumorigenic role in established tumors and consequently the vast majority of clinical trials focus on autophagy inhibition in cancer. Over the last decade, a dozen Phase I and I/II clinical trials have been completed and published using the autophagy inhibitors, Chloroquine CQ or hydroxychloroquine HCQ in cancer. These lysosomal targeting compounds were originally approved for use in humans as anti-malarial drugs but have been repurposed as autophagy targeting cancer.

     
  7. ivbco New Member

    Plaquenil is the brand name for the prescription drug hydroxychloroquine. Plaquenil and muscle aches and pains? Plaquenil vs. Aralen Prescription Treatment for Malaria Differences. Hydroxychloroquine - thigh muscle weakness?
     
  8. dima3232 New Member

    Three diverse mechanisms have been proposed to explain the antimalarial activity of chloroquine: binding to DNA, binding to hemin, or alkalinizing parasite lysosomes. Chloroquine diphosphate ≥99%HPLC Selleck ATM/ATR. Inhibition of Nucleic Acid Synthesis by Antibiotics. Chapter 12 Quiz Questions 2 IMPORTED Flashcards Quizlet
     
  9. kundalini Moderator

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    Relapsed Hydroxychloroquine Induced Thrombocytopenia in.