Hydroxychloroquine usmle mechanism of action

Discussion in 'Canadian Pharmacies Online' started by SWhy, 01-Mar-2020.

  1. siberian Moderator

    Hydroxychloroquine usmle mechanism of action


    It is also useful in treating systemic lupus erythematosus as well as rheumatoid arthritis and Sjögren's Syndrome (all rheumatic disorders). While hydroxychloroquine has been known for some time to increase[1] lysosomal p H in antigen presenting cells, its mechanism of action in inflammatory conditions has been recently elucidated and involves blocking the activation of toll-like receptors on plasmacytoid dendritic cells (PDCs).

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    While hydroxychloroquine has been known for some time to increase1 lysosomal pH in antigen presenting cells, its mechanism of action in inflammatory conditions has been recently elucidated and involves blocking the activation of toll-like receptors on plasmacytoid dendritic cells PDCs. Hydroxychloroquine HCQ is an alkalinizing lysosomatropic drug that accumulates in lysosomes where it inhibits some important functions by increasing the pH. HCQ has proved to be effective in a number of autoimmune diseases including systemic lupus erythematosus SLE. According to Raoult, the effect of both chloroquine and its derivative hydroxychloroquine is probably the same since the mechanism of action of these two closely-related molecules is identical, he.

    Hydroxychloroquine, by decreasing TLR signaling, reduces the activation of dendritic cells thus mitigating the inflammatory process. Toll-like receptor 9 (TLR 9), which recognizes DNA-containing immune complexes, leads to the production of interferon and causes the dendritic cells to mature and present antigen to T cells.

    Hydroxychloroquine usmle mechanism of action

    USMLE/COMLEX Step 1 Pharmacology One Liners - Quizlet, PDF Hydroxychloroquine in systemic lupus erythematosus SLE

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  6. The major proposed mechanisms of action of antimalarials on the immune system include 1 interference with lysosomal acidification and inhibition of proteolysis, chemotaxis, phagocytosis, and antigen presentation 9, 10; 2 decreasing macrophage-mediated cytokine production, especially interleukin IL-1 and IL-6 ; 3 inhibition of phospholipase A2 and thereby antagonizing the effects of prostaglandins 12, 13; 4 absorption and blocking of UV light cutaneous reactions ; 5 binding.

    • Hydroxychloroquine From Malaria to Autoimmunity SpringerLink.
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    Chloroquine and hydroxychloroquine are drugs derived from the quinoline molecule. Both are used as antimalarial blood schizonticides, and hydroxychloroquine is also frequently used as an antirheumatic. Their mechanism of action is not entirely understood. However, despite their varying therapeutic dosage and toxicity. Disease-modifying antirheumatic drugs DMARDs are a group of medications commonly used in people with rheumatoid arthritis. Some of these drugs are also used in treating other conditions such as ankylosing spondylitis, psoriatic arthritis, and systemic lupus erythematosus. They work to decrease pain and inflammation. Hydroxychloroquine Plaquenil is considered a disease-modifying anti-rheumatic drug DMARD. It can decrease the pain and swelling of arthritis. It may prevent joint damage and reduce the risk of long-term disability. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria.

     
  7. maximYCH Well-Known Member

    Neck pain and headaches are often connected because a stiff neck, herniated cervical disc, or irritated spinal nerves can cause headaches. Sudden onset of neck pain - Why Does My Neck Hurt? Neck Pain Causes & Treatment Rheumatoid Arthritis Guide Causes, Symptoms and Treatment.
     
  8. Dogorovv Well-Known Member

    Dermatomyositis - Diagnosis and treatment - Mayo Clinic A scanner creates cross-sectional images of your muscles from data generated by a powerful magnetic field and radio waves. Unlike a muscle biopsy, an MRI can assess inflammation over a large area of muscle. Skin or muscle biopsy. A small piece of skin or muscle is removed for laboratory analysis.

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