Chloroquine mechanism of resistance

Discussion in 'Canadian Pharmacies Online' started by Berni, 25-Feb-2020.

  1. newpower Moderator

    Chloroquine mechanism of resistance


    However, the reason for the lower accumulation of chloroquine was unknown. The resistant parasite has now been found to release chloroquine 40 to 50 times more rapidly than the susceptible parasite, although their initial rates of chloroquine accumulation are the same.

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    Learn about Chloroquine Mechanism of action and resistance in 2 minutes. Presenter Dr. Tanmay Mehta MD, DNB, PGDCTM Chloroquine Research by German scientists to discover a substitute for quinine led to the synthesis in 1934 of Resochin chloroquine and Sontochin 3-methyl-chloroquine. These compounds belonged to a new class of antimalarials, the four-amino quinolines. The combination of chloroquine with zinc enhanced chloroquine’s cytotoxicity and induced apoptosis in A2780 cells. Thus chloroquine is a zinc ionophore, a property that may contribute to chloroquine’s anticancer activity. Chloroquine inhibits the intracellular multiplication of Legionella pneumophila by limiting the availability of iron.

    These results suggest that a higher rate of chloroquine release explains the lower chloroquine accumulation, and thus the resistance observed in resistant Plasmodium falciparum. Verapamil and two other calcium channel blockers, as well as vinblastine and daunomycin, each slowed the release and increased the accumulation of chloroquine by resistant (but not susceptible) Plasmodium falciparum.

    Chloroquine mechanism of resistance

    Chloroquine - FDA prescribing information, side effects and uses, History of antimalarials Medicines for Malaria Venture

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  7. Recently, an altered chloroquine-transporter protein CG2 of the parasite has been related to chloroquine resistance, but other mechanisms of resistance also appear to be involved. Research on the mechanism of chloroquine and how the parasite has acquired chloroquine resistance is still ongoing, as other mechanisms of resistance are likely.

    • Chloroquine - Wikipedia.
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    • Chloroquine – howMed.

    Causes of resistance 12 3.1 Definition of antimalarial drug resistance 12 3.2 Malaria treatment failure 12 3.3 Mechanisms of antimalarial resistance 12 3.3.1 Chloroquine resistance 12 3.3.2 Antifolate combination drugs 13 3.3.3 Atovaquone 13 3.4 Factors contributing to the spread of resistance 13 3.4.1 Biological influences on resistance 13 Chloroquine is a 4-aminoquinoline with antimalarial, anti-inflammatory, and potential chemosensitization and radiosensitization activities. Although the mechanism is not well understood, chloroquine is shown to inhibit the parasitic enzyme heme polymerase that converts the toxic heme into non-toxic hemazoin, thereby resulting in the accumulation of toxic heme within the parasite. Mechanisms of Drug Action and Resistance Focus on Antimalarials Chemotherapy is the primary means of treating protozoan infections. Successful chemotherapy depends in a large part on the ability to exploit metabolic differences between the pathogen and the host.

     
  8. mods Well-Known Member

    Retinal complications from HCQ are actually rare (at proper dosage) and, with good screening, the risk for visual loss is very low. Does Patient with Lupus Have Plaquenil Retinopathy? Early Plaquenil Toxicity Detected without Bull’s Eye. Retinal toxicity associated with chronic exposure to.
     
  9. sie Moderator

    Hydroxychloroquine is a quinoline medicine used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Príbalový leták Plaquenil 200 mg - ADC.sk HYDROXYCHLOROQUINE SULFATE 200 mg filmsko obložena tableta. Hydroxychloroquine Plaquenil Side Effects & Dosage for Malaria
     
  10. neiro Moderator

    Chloroquine Uses, Side Effects & Warnings - Chloroquine is used to treat and to prevent malaria. Chloroquine is also used to treat amebiasis infection caused by amoebae. Chloroquine may also be used for purposes not listed in this medication guide.

    What Are Malaria Pills? - WebMD