I have been on plaquenil for over a year and a half and methotrexate since September. I get my eyes checked every six months and I am now at once a month on blood work for my liver enzymes (used to be every 2 weeks). I have lupus which mainly affects my joints and skin. One affects your eyes more and one affects your liver more. I would appreciate any comments or advice from everyone. Wannabe Hi, I am on both methotrexate and plaquenil. Wannabe To Be Free To Roam Sorry to hear that you are having a lot of pain with your RA. How does plaquenil help lupus New plaquenil dosing guidelines Hydroxychloroquine is commonly used alongside other disease-modifying drugs including methotrexate – especially for rheumatoid arthritis. However, some drugs can interact with hydroxychloroquine. Indigestion remedies for example, antacids including some over-the-counter preparations can stop hydroxychloroquine being absorbed. The study is based on methotrexate sodium and hydroxychloroquine sulfate the active ingredients of Methotrexate and Plaquenil, respectively, and Methotrexate and Plaquenil the brand names. Other drugs that have the same active ingredients e.g. generic drugs are not considered. I know Plaquenil has helped me a ton, because I tried going off of it once to see if I really needed it. The first two weeks weren't bad, as Plaquenil has a high half-life and there was still some Plaquenil in my body. After that, my Lupus got progressively worse until I gave up and re-started the Plaquenil after 6 weeks of being off it. I wish you well with this decision and the results. Your chances of problems with the methotrexate are a bit larger. deductible (I am at about $2,500 - $3,000 right now). My rheumy recently added Imuran (instead of methotrexate). So, what do yall know about the side effects of both and the benefits of both? Methotrexate and hydroxychloroquine Methotrexate Side-effects, uses, time to work, Methotrexate and Plaquenil drug interactions - eHealthMe Chloroquine premaquinPlaquenil patient reviewsChloroquine: mechanism of drug action and resistance in plasmodium falciparumHydroxychloroquine plaquenil pharmacological drug classHow to wean from plaquenil I was diagnosed with RA in march and have been on increasing dose of methotrexate. Yesterday my rheumatologist started me on hydroxychloroquine as well. Is anyone else on this combination and have you had any problems with it as I know hydroxychloroquine can cause eye sight problems. Thanks Does anyone take methotrexate and hydroxychloroquine. - NRAS. Methotrexate vs. Plaquenil - Autoimmune diseases - Inspire. Methotrexate and its benefit for Sjögren’s patients. Curcumin in turmeric may increase the therapeutic action of arthritis medications and protect from their side effects as well. Let’s examine the scientific details behind the safety of taking turmeric and curcumin with arthritis medications. 1. Curcumin may change drug absorption. Turmeric and curcumin are safe for consumption. Methotrexate–hydroxychloroquine combination therapy may cause lower disease activity in early RA than methotrexate monotherapy. Methotrexate monotherapy as first early RA treatment seems to lead to more treatment intensification. Methotrexate Moderate Hydroxychloroquine may reduce the renal clearance of methotrexate; the exact mechanism of this interaction is unknown. The mean AUC of methotrexate was increased 52% and the mean Cmax was reduced 17% when a single dose of methotrexate was given with a dose of hydroxychloroquine 200 mg oral.