Calcium chloroquine autophagy review

Discussion in 'Canadian Pharmaceuticals Online' started by Lev, 17-Mar-2020.

  1. StarX XenForo Moderator

    Calcium chloroquine autophagy review


    As regards cancer, autophagy may play a tumor suppressive role by preserving cellular integrity during tumor development and by possible contribution to cell death. However, autophagy may also exert oncogenic effects by promoting tumor cell survival and preventing cell death, for example, upon anticancer treatment.

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    The endoplasmic reticulum ER is a major intracellular store of Ca 2+, with a resting Ca 2+ concentration of several hundred μM 4. This composes a dynamic pool of Ca 2+ that functions in processes ranging from proliferation to cell death, and of note, autophagy. Chloroquine is commonly used to study the role of endosomal acidification in cellular processes 2, 3, such as the signaling of intracellular TLRs. Moreover, Chloroquine inhibits autophagy as it raises the lysosomal pH, which leads to inhibition of both fusion of autophagosome with lysosome and lysosomal protein degradation 4. Autophagy is a highly conserved catabolic process induced under various conditions of cellular stress, which prevents cell damage and promotes survival in the event of energy or nutrient shortage and responds to various cytotoxic insults.

    Glucose transporters, mainly from GLUT family, which are often upregulated in cancer, are also prominent targets for autophagy induction. The major factors influencing autophagy are Ca channels like voltage-gated T- and L-type channels, IP3 receptors, or CRAC are involved in autophagy regulation.

    Calcium chloroquine autophagy review

    Autophagy During Cardiac Stress Joys and. - Annual Reviews, Chloroquine & Hydroxychloroquine supporting chemo.

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  5. Autophagy is a key pathway in the development of endocrine resistance in breast cancer, and targeting autophagy can reverse antiestrogen resistance. Chloroquine, an anti-malarial drug, inhibits autophagy by preventing degradation of autolysosomes.

    • Hydroxychloroquine inhibits autophagy. - PubMed Central PMC.
    • Mechanism and medical implications of mammalian autophagy..
    • Autophagy During Cardiac Stress Joys and Frustrations. - Annual Reviews.

    The role of calcium and calcium-permeable channels in cancer is well-established, whereas the information about molecular nature of channels regulating autophagy and the mechanisms of this regulation is still limited. Here we review existing mechanisms of autophagy regulation by calcium and calcium-permeable ion channels. Hypoxia can induce autophagy, which is activated in response to protein aggregates, in the proteotoxic forms of cardiac diseases. Previous studies suggested that autophagy can protect cells by avoiding accumulation of misfolded proteins, which can be generated in response to ischemia/reperfusion I/R injury. Verapamil, the L-type calcium channel blocker, induced autophagy-like processinhumanadenocarcinomaCOLOcellsasjudged by ultrastructural studies. e other L-type calcium channel blocker, nifedipine, decreased proliferation and migration and evoked autophagy in endometrial carcinoma HEC-A cells.

     
  6. JeanGabin New Member

    the cause of the most lethal human malaria, chloroquine resistance is linked to multiple mutations in Pf CRT, a protein that likely functions as a transporter in the parasite’s digestive vacuole membrane. Emergence of P. vivax resistance to chloroquine in French. Distribution of Mutations Associated with Antifolate and. CDC - Malaria - Diagnosis & Treatment United States.
     
  7. alt-f4 XenForo Moderator

    Hydroxychloroquine - Side Effects, Dosage, Interactions - Drugs. Hydroxychloroquine is used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia. This medicine is not effective against all strains of malaria.

    Hydroxychloroquine Side-effects, uses, time to work
     
  8. KOL User

    Mixing Alcohol and Clonazepam Klonopin Signs and Effects There are a variety of concurrent alcohol and clonazepam abuse problems to be aware of, which include a higher risk of addiction and the type of side effects you might be experiencing. Each side effect you experience while taking clonazepam is heightened when you are also drinking alcohol.

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