The most common side effect associated with its use is retinal toxicity, which may be irreversible. Therefore, it is pertinent to know the findings, risk factors, and screening tests necessary to prevent retinal damage. Plaquenil and blood glucose Chloroquine systemic lupus erythematosus Can plaquenil cause low platelets Hydroxychloroquine skin rash This occurs when melanin is able to bind to the “High Risk Medication” Plaquenil within the Retinal Pigment Epithelium RPE as well as direct toxicity to retinal ganglion cells. The drugs ability to bind to these pigmented cells creates a “Bulls Eye” around the macula, giving it this very unique appearance. Once retinal toxicity from hydroxychloroquine occurs, it is thought that the retinal changes are permanent and the disease can progress even if hydroxychloroquine is stopped for 1 to 3 years. Newer techniques for evaluation of retinal disease have been developed and these techniques can detect retinal toxicity earlier. Sep 15, 2014 Hydroxychloroquine sulfate HCQ, Plaquenil is an analogue of chloroquine CQ, an antimalarial agent, used for the treatment of systemic lupus erythematosus, rheumatoid arthritis and other autoimmune disorders. Its use has been associated with severe retinal toxicity, requiring a discontinuation of therapy. During the first five years of use, the rate of toxicity was found to be 0.7%, rising significantly to more than 1% after five to seven years of use. The prevalence of retinal toxicity has varied among different studies. Retinal toxicity plaquenil Early Plaquenil Toxicity Detected without Bull’s Eye Maculopathy, My Take on New Ocular Screening Guidelines for Plaquenil. Is plaquenil quinineAutophagic flux assay chloroquineBull's eye maculopathy plaquenilHow long does hydroxychloroquine need to heal jointsPlaquenil et prise de poids This article is from June 2011 and may contain outdated material. Download PDF. Many systemic medications may cause retinal toxicity. One such commonly used medication for dermatologic and rheumatologic inflammatory conditions is hydroxychloroquine Plaquenil, a chloroquine derivative. Hydroxychloroquine-Induced Retinal Toxicity - American.. Retinal toxicity associated with chronic exposure to.. Multimodal Imaging in Plaquenil Toxicity. Nov 01, 2015 H ydroxychloroquine HCQ; Plaquenil, Sanofi, Bridgewater, NJ is an antimalarial agent that is also commonly used as a treatment for a variety of rheumatologic and dermatologic conditions, such as rheumatoid arthritis and systemic lupus erythematosus. The most common side effect associated with its use is retinal toxicity, which may be. Plaquenil Toxicity Plaquenil hydroxychloroquine is a medicine commonly used to treat patients with systemic lupus erythematosus and rheumatoid arthritis. After prolonged use, it can sometimes damage the macula and cause central vision loss. If we extrapolate the use of long-term hydroxychloroquine at KPNC to the entire US population, approximately 350 000 patients should receive annual eye screening by current guidelines. 9 Therefore, screening for hydroxychloroquine retinal toxicity is an important economic and patient safety issue. Retinal toxicity from hydroxychloroquine use cannot be completely prevented, but effective screening should recognize retinal toxicity before symptoms or significant risk of central visual field.