Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it. Chloroquine brand Chloroquine diphosphate packaging Does plaquenil work It is so far not known whether chloroquine could impair the Hb clearance pathway of human macrophages. Although chloroquine has been largely abandoned as an antimalarial agent due to widespread emergence of resistant parasitic strains and availability of alternative medications 19, 20, clinical interest was regained in recent years, based on. In this study, BCRP-1 was found to be expressed on macrophages of human origin and on foamy giant cells at the site of MTB infection. In the current in vitro study, interferon-gamma IFNγ increased the expression of BCRP-1 in macrophages derived from the human monocytic leukaemia cell line THP-1. Chloroquine Phosphate is the phosphate salt of chloroquine, a quinoline compound with antimalarial and anti-inflammatory properties. Chloroquine is the most widely used drug against malaria, except for those cases caused by chloroquine resistant Plasmodium falciparum. The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead. Chloroquine macrophages Chloroquine Interference with Hemoglobin Endocytic., Chloroquine enhances the antimycobacterial activity of isoniazid and. Fluorescein angiography and hydroxychloroquine maculopathy screening Chloroquine decreased the NO production by murine peritoneal macrophages treated with interferon-γ for 24 and 48 h at concentration as low as 1 μM. Incubation of murine peritoneal macrophages with chloroquine for 2 h before induction with interferon-γ also reduced nitrite formation, but higher concentrations of chloroquine 10 μM or over, Fig. 2A were required. Action of chloroquine on nitric oxide production and parasite.. Chloroquine phosphate C18H32ClN3O8P2 - PubChem. Phosphoantigen Presentation by Macrophages to Mycobacterium.. TY - JOUR. T1 - A chloroquine-induced macrophage-preconditioning strategy for improved nanodelivery. AU - Wolfram, Joy. AU - Nizzero, Sara. AU - Liu, Haoran Resetting tumor-associated macrophages TAMs is a promising strategy to ameliorate the immunosuppressive tumor microenvironment and improve innate and adaptive antitumor immunity. Here we show that chloroquine CQ, a proven anti-malarial drug, can function as an antitumor immune modulator that switches TAMs from M2 to tumor-killing M1 phenotype. Agents, such as chloroquine CQ, have been implicated as chemo-sensitizers 10, 11. In fact, several clinical tri-als have evaluated the ability of CQ to enhance the effi-cacy of chemotherapy in a variety of cancer treatments NCT00969306, NCT02432417 12–14. Moreover, CQ has been widely studied as an immune modulator in macrophages 15, 16.