It also associated with rheumatic disorders such as rheumatoid arthritis, and it is rheumatoid factor positive in 90 percent of cases. Reading the warnings, I see that there is concern about effects on the eyes (retinas). I am very concerned about this and am wondering if anyone out there has been put on an alternative drug to treat their SS. Easily bruising side effect of plaquenil Chloroquine po 300 mg daily prophylaxis Plaquenil corneal deposits Can hydroxychloroquine cause weight gain I am taking Plaquenil since 10 there are side effects,but your doctor also will check your blood on a regular basis and would detect right away if there would be something wrong with your liver or you have Lupus, it would be more dangerous for your inner organs,if you wouldn`t take any medications. I had an allergic reaction to plaquenil when I was first diagnosed with lupus. My rheumatologist put me on chloroquine and I have been on that for the last 5 years. My flare ups have been minimal on the chloroquine. I do have to go for eye checks just like plaquenil. But I’ve had good luck with this so far. Maybe it’s worth a try! Goodluck. I originally took Plaquenil Sanofi but this brand is now discontinued. The generic form of this, on my prescription, gives me serious digestion and stomach upsets to a point I spent months trying to figure out what I thought was irritable bowel syndrome. Has anyone found a good alternative UK brand that doesn't create this side affect. The side effects of these medications are far scarier! I have several issues with my retinas already, and don't feel comfortable putting them at more risk. There are other medications but they're usually saved for those with a more severe disease, particularly joint problems. Alternatives to plaquenil for lupus Plaquenil hydroxychloroquine Alternatives & Similar., Alternatives to Hydroxychloroquine - Lupus - Inspire Plaquenil eye problemsHow long is plaquenil goodChloroquine pharmacology The alternative to Plaquenil is a slightly different anti malarial called Quinacrine. Plaquenil replaced Quinacrine formerly called Atabrine for anti malarial prophylaxis so now the Quinacrine has to be made up into pills or gel capsules by a compounding pharmacy. If you google you will find details of compounding pharmacies. Discontinued Plaquenil.other options?. Hydroxychloroquine - Plaquenil Alternative - LUPUS UK. Alternatives to plaquenil Anti-Inflammatories discussions.. May be I've asked this question before in some other form, but I really would like to know if there is an alternative to Plaquenil. Plaquenil was the only drug for me which gave me instantaneous better saliva flow + improved my depression within a week. I have a long list of medication that I am allergic to including NSAIDs and plaquenil. A few years ago at the time she finally had enough evidence to call lupus not zero-negative RA we tried methotrexate. The starter dose landed me in hospital with anaphylaxis. Because of this my rheumatologist is very hesitant to play around with my meds. Hello! Here is a short list Prednisone, Imuran, Remicade, Methotrexate Later sidesteps Prednisone's side effects, which include weight gain, mood swings, diabetes and eye problems, such as cataracts. I hope this was helpful enough.