Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Plaquenil psoriatic arthritis Hydroxychloroquine sulfate drug class The risk of a toxicity sharply increases after 5 years, with majority of cases of retinotoxicity occurring in patients that have had a cumulative dose exceeding 1000g of hydroxychloriquine Plaquenil. This level is reached in about 7 years with the most common daily dose of Plaquenil, 400 mg/day 200 bid. Sep 15, 2014 Hydroxychloroquine sulfate HCQ, Plaquenil is an analogue of chloroquine CQ, an antimalarial agent, used for the treatment of systemic lupus erythematosus, rheumatoid arthritis and other autoimmune disorders. Its use has been associated with severe retinal toxicity, requiring a discontinuation of therapy. Hydroxychloroquine Retinal Toxicity and Daily Use by Real Body Weight vs Ideal Body Weight. A, Receiver operating characteristic ROC curve of the prediction of retinal toxicity by real body weight compared with ideal body weight. The difference in the area under the ROC curves is significant P =.03. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Hydroxychloroquine retinal toxicity Determine risk for hydroxychloroquine retinal toxicity., Retinal toxicity associated with chronic exposure to. Plaquenil prevent lupusCan plaquenil cause anxiety Factors that increase the risk of developing hydroxychloroquine associated retinal toxicity include daily dose, cumulative dose, renal or liver impairment, older age, and prior retinal disease. Specifically, a daily dose of 6.5mg/kg based on ideal body weight and a cumulative dose of 1000g of hydroxychloroquine or 460g of chloroquine are both considered risk factors for retinal toxicity. Retinal Screening for Hydroxychloroquine Plaquenil Toxicity.. Toxic Retinopathy With Hydroxychloroquine Therapy. Hydroxychloroquine toxicity - EyeWiki. Hydroxychloroquine is associated with long-recognized retinal toxicity. 2, 3, 4 The retinopathy is hallmarked by parafoveal changes within the retina. Early toxicity may be asymptomatic. Chloroquine and hydroxychloroquine bind to melanin in the retinal pigment epithelium RPE and cause damage to the macular cones outside of the fovea. The drugs inhibit RPE lysosome activity, reduce phagocytosis of shed photoreceptor outer segments causing an accumulation of outer receptor segments. AT A GLANCE • Long-term use of hydroxychloroquine sulfate may result in parafoveal retinal toxicity. • No single imaging platform can confirm the presence of hydroxychloroquine toxicity. • Microperimetry and adaptive optics are undergoing studies to confirm their usefulness in.