Hydroxychloroquine-mediated retinopathy

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  1. Name Moderator

    Hydroxychloroquine-mediated retinopathy

    Ophthalmic surveillance was performed on patients in a multicenter clinical trial testing high-dose (1000 mg daily) hydroxychloroquine for advanced non–small cell lung cancer. The US Food & Drug Administration–recommended screening protocol included only visual acuity testing, dilated fundus examination, Amsler grid testing, and color vision testing.

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    A study of about 200 patients with a history of hydroxychloroquine retinopathy, including 36 Asian patients, found that the pericentral pattern occurred in half the Asian patients but only 2% of the white patients. 31 The mechanism for this finding is unclear, but because pericentral retinopathy spares the macula, it can be missed using standard screening methods. Asian patients with HCQ retinopathy typically present with a pericentral pattern of retinopathy; that is, such patients show retinal toxicity in the more peripheral retina than white patients.3, 4, 5 However, the extent of retinopathy in Asian patients or how wide the retinopathy can advance remains unclear. Hydroxychloroquine is a front-line treatment for systemic lupus erythematosus and other rheumatic diseases, but can cause retinopathy. Improved detection techniques for the early stages pre.

    Out of the 7 patients having exposure of at least 6 months, 2 developed retinal toxicity (at 11 and 17 months of exposure). In patients seen at Stanford, additional sensitive screening procedures were added at the discretion of the retinal physician: high-resolution spectral-domain optical coherence tomography (OCT), fundus autofluorescence (FAF) imaging, Humphrey visual field (HVF) testing, and multifocal electroretinography (mf ERG).

    Hydroxychloroquine-mediated retinopathy

    Autoimmune retinopathy associated - Digital Commons, Evaluation of Hydroxychloroquine Retinopathy Using Ultra.

  2. Hydroxychloroquine hypoglycemia
  3. Megan B. Goodman, Ari Ziskind, Fundus auto fluorescence and spectral domain ocular coherence tomography in the early detection of chloroquine retinopathy, African Vision and Eye Health, 2015, 74, 1CrossRef; 19 Junyeop Lee, Joo Yong Lee, Hydroxychloroquine Retinopathy, Journal of Rheumatic Diseases, 2015, 22, 3, 140CrossRef

    • Incidence of hydroxychloroquine retinopathy in 1,207..
    • Hydroxychloroquine retinopathy — implications of research..
    • Pharmacology of Chloroquine and Hydroxychloroquine SpringerLink.

    Chloroquine is a 9-aminoquinoline known since 1934. Apart from its well-known antimalarial effects, the drug has interesting biochemical properties that might be applied against some viral infections. Chloroquine exerts direct antiviral effects, inhibiting pH-dependent steps of the replication of several viruses including members of the flaviviruses, retroviruses, and coronaviruses. Its best. Hydroxychloroquine to Increase Tumor Suppressor PAR-4 Levels in Oligometastatic Prostate Cancer - Full Text View. Retinopathy, hyperpigmentation, myopathy, and skin reactions.1 Retinopathy Retinopathy’s irreversibility—the threat of permanent vision loss—and its substantial prevalence in patients with a large drug expo-. a

  4. OsakaMan User

    Acquiring HCQ is easier than CQ in some areas, so I have done some research to find some literature on HCQ. Plaquenil Guidelines Point Out New Risks, New Presentation - American. Hydroxychloroquine? any good? - Sarcoidosis - Inspire Stopping Plaquenil - General Discussion - Life With Lupus
  5. sabotage Moderator

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  6. Sashurik2004 Well-Known Member

    Chloroquine Aralen - Side Effects, Dosage, Interactions - Drugs Chloroquine Aralen is used for preventing and treating malaria and amebiasis, an infection of the intestines caused by a parasite. Chloroquine Aralen - Side Effects, Dosage, Interactions.

    Side Effects of Aralen Chloroquine, Warnings, Uses
  7. jake Well-Known Member

    Quitting Plaquenil after 2 years - Sjogren's World Jan 27, 2010 Update on Quitting Plaquenil. I've been totally off of it for one week. I'm doing OK. The main thing I noticed was that at the end of 2 weeks on half dose of 200 mg day, the weird dreams cooled out and I started sleeping MUCH better. I have actually been waking up only once per night which is like a gift of the gods to me. So mentally, I'm.

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