Malaria is common in areas such as Africa, South America, and Southern Asia. This medicine is not effective against all strains of malaria. How long can i stay on plaquenil Retinal thickness changes plaquenil toxicity Hydroxychloroquine Plaquenil, chloroquine Aralen, and quinacrine Atabrine are medications that were originally used to prevent or treat malaria. However, during World War II it was also found that these medications were effective in treating the symptoms of lupus. May be I've asked this question before in some other form, but I really would like to know if there is an alternative to Plaquenil. Plaquenil was the only drug for me which gave me instantaneous better saliva flow + improved my depression within a week. Is there a drug that I can take to replace plaquenil? Asked by tanner01. there are several drugs now that you can take instead of the plaquenil. these type of drugs they have now work in a different way then the methotrexate and plaquenil. most of these drugs you will still take the methotrexate. i researched these drugs before i. Taking hydroxychloroquine long-term or at high doses may cause irreversible damage to the retina of your eye. Hydroxychloroquine is also an antirheumatic medicine and is used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. Hydroxychloroquine substitutions PLAQUENIL Patient Assistance Program, Is there an alternative to Plaquenil? Effects of plaquenil on the eyes Hydroxychloroquine is used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia. This medicine is not effective against all strains of malaria. Hydroxychloroquine - Side Effects, Dosage, Interactions.. Is there a drug that I can take to replace plaquenil?. Compare Plaquenil vs Chloroquine -. How to use Hydroxychloroquine SULFATE. Hydroxychloroquine is usually taken with food or milk to prevent stomach upset. The dosage and length of treatment are based on your medical condition and response to therapy. In children, dosage is also based on weight. Hydroxychloroquine generally does not have significant interactions with other medications, but care should be taken if combined with medication altering liver function as well as aurothioglucose Solganal, cimetidine Tagamet or digoxin Lanoxin. Autoimmune hepatitis is a disease in which the body’s immune system attacks liver cells of the same organism. This causes the liver to become inflamed, resulting in hepatitis.