Malaria is common in areas such as Africa, South America, and Southern Asia. This medicine is not effective against all strains of malaria. Ear pressure from plaquenil G6pd chloroquine Special eye exams for people on plaquenil Haemolysis in patients with glucose-6-phosphate dehydrogenase G6PD deficiency, aplastic anaemia, and leukopenia has been reported. The most extensive study to date evaluating G6PD deficiency with concurrent use of hydroxychloroquine reported no episodes of haemolysis in over 700 months of exposure among the 11 studied patients with G6PD. G6PD deficiency Although the manufacturer's labeling recommends hydroxychloroquine be used with caution in patients with G6PD deficiency due to a potential for hemolytic anemia, there is limited data to support this risk. Rarely, hydroxychloroquine can lead to anemia in some individuals. This can happen in individuals with a condition known as G6PD deficiency or porphyria. In rare cases, hydroxychloroquine can cause visual changes or loss of vision. Such vision problems are more likely to occur in individuals taking high doses for many Taking hydroxychloroquine long-term or at high doses may cause irreversible damage to the retina of your eye. Hydroxychloroquine is also an antirheumatic medicine and is used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. Hydroxychloroquine g6pd Hydroxychloroquine Is Not Associated with Hemolytic Anemia., Hydroxychloroquine Professional Patient Advice - Ldn and plaquenilPlaquenil eye damage reversibleDoes hydroxychloroquine interact with levothryoxinePlaquenil gut bacteria OBJECTIVE Some sources urge caution when prescribing hydroxychloroquine HCQ to patients with G6PDH deficiency, presumably due to a risk of hemolytic anemia. There are limited published data, however, to support this risk. Examination of Hydroxychloroquine Use and Hemolytic Anemia.. PATIENT FACT SHEET Hydroxychloroquine Plaquenil. Hydroxychloroquine not linked with hemolytic anemia in.. WebMD provides common contraindications for Plaquenil Oral. Find out what health conditions may be a health risk when taken with Plaquenil Oral Glucose-6-phosphate dehydrogenase G6PD deficiency is an inherited disorder caused by a genetic defect in the red blood cell RBC enzyme G6PD, which generates NADPH and protects RBCs from oxidative injury. G6PD deficiency is the most common enzymatic disorder of RBCs. If mutations in the G6PD gene reduce the amount of glucose-6-phosphate dehydrogenase or alter its structure, this enzyme can no longer play its protective role. As a result, reactive oxygen species can accumulate and damage red blood cells.