Yesterday my rheumatologist started me on hydroxychloroquine as well. Is anyone else on this combination and have you had any problems with it as I know hydroxychloroquine can cause eye sight problems. Glaucoma and plaquenil Plaquenil vs hydroxycholorquine sulfate Plaquenil hydroxychloroquine and Rheumatrex and Trexall methotrexate are used to treat rheumatoid arthritis. Plaquenil is also used to treat or prevent malaria, and to treat symptoms of discoid or systemic lupus erythematosus. Rheumatrex and Trexall are also used to treat some cancers and severe skin diseases such as severe psoriasis. If you search the forums for the word "methotrexate" you will get a lot of good info on that alternative. It's often the next step up from Plaquenil because it's been so well-studied, and is very effective for many people. It's not without drawbacks, of course - no drug is - but it's better than letting the disease eat you up! Plaquenil is a slow-acting drug, meaning that it can take up to 6 months to experience the full benefits of this medication, but it is possible for symptoms to improve in as few as 1 or 2 months. Plaquenil and other antimalarials are the key to controlling lupus long-term, and some lupus patients may be on Plaquenil for the rest of their lives. Recently my eyes have felt sore and, after posting a question on this site, I am seeing my GP on Monday. Thanks Hi Catjones I have been taking this combination, started on both of them in January this year. Does plaquenil work without methotrexate Plaquenil Hydroxychloroquine - Side Effects, Dosage., What step comes after plaquenil? Side effects of discontinuing plaquenilWhat does chloroquine treatDescribe eye tests for plaquenilWhat happens when you stop taking plaquenil I was on both for 2 years without a problem, I've stopped taking plaquenil but am still on 20mg methotrexate per week for closer to 3 years now without incident. Yes it's scary to begin with but when your quality of life slowly returns it's all worthwhile. Methotrexate and plaquenil - @Kristinsaba1988.. Plaquenil What You Need to Know - Kaleidoscope Fighting Lupus. Does anyone take methotrexate and hydroxychloroquine.. Is plaquenil hydroxychloroquine with methotrexate without prednisone an effective treatment for moderate to sev more Is plaquenil hydroxychloroquine with methotrexate without prednisone an effective treatment for moderate to severe rheumatoid arthritis ? Hydroxychloroquine brand namePlaquenil is a disease-modifying anti-rheumatic drug DMARD approved for adults with RA. It is often given in combination with methotrexate and sulfasalazine a treatment known as triple therapy, to help slow RA disease progression for patients who do not get relief from methotrexate therapy alone. 1,2 They had my on plaquenil initially for seronegative RA and it didn't help with my symptoms - I also had similar side effects and lost some hair which isn't ideal when you're 21 lol I'm on methotrexate now and I have some GI side effects and brain fog and whatnot, but they're tolerable.