Affecting my self esteem Your definitely not alone. I’m fair hair n skin but I’m getting brown blotches. I am not looking to when it starts coming down my face hope I can b helped in time. Porqué tomar plaquenil y no otros medicamentos biologicos What is the best time of day to take plaquenil Plaquenil received an overall rating of 5 out of 10 stars from 4 reviews. See what others have said about Plaquenil, including the effectiveness, ease of use and side effects. Plaquenil Reviews. Each white-to-off-white, film-coated, peanut-shaped tablet with "PLAQUENIL" in black on one side contains 200 mg of hydroxychloroquine sulfate equivalent to 155 mg of base. Nonmedicinal ingredients black ink, calcium hydrogenophosphate, carnauba wax, corn starch, magnesium stearate, opadry White YS-I-7443, and polyethylene glycol 400. Plaquenil can cause pigment discolouration in the skin. I have two darker patches on the sides of my face which developed quite some time after taking it. It sort of looks like parts of my face are in the shade It might be the cause of your brown spots as well? I also notice that the skin affected feels rougher as well. My scalp has turned black and my forehead side of face r slowly turning ears r totally black shiny plate .various long and boring treatments from docs but to no avail.finally I have been asked to stopped taking h for lupus for 3 next step will b decided. I am surprised to hear about this cos my rheumy said hydroxy helps to lighten the skin. One of them is on my nose and people keep telling me I’ve a dirt mark. I'm from Indian sub continent and am a "woman of colour like urself" approx 2 years ago had sudden deep painful itch in scalp and body. Yes I have been on this med since 2003 and I have black patches all over. Plaquenil dark spots Long-Term Side Effects of Plaquenil for Rheumatoid., Plaquenil - Uses, Side Effects, Interactions - Hydroxy chloroquine 400 mgMalaria chloroquine resistant areas Sore throat sores, ulcers, or white spots on the lips or in the mouth sticking out of the tongue stomach pain swelling of the feet or lower legs swollen or painful glands trouble with breathing, speaking, or swallowing uncontrolled twisting movements of the neck, trunk, arms, or legs unusual behavior unusual bleeding or bruising Hydroxychloroquine Oral Route Side Effects - Mayo Clinic. Brown spots/discoloration on your face. Lupus Forums at.. Purple Spots on Skin, Pictures, Small, Purpura, Causes.. Importance Hydroxychloroquine-induced pigmentation is not a rare adverse effect. Our data support the hypothesis that hydroxychloroquine-induced pigmentation is secondary to ecchymosis or bruising. Objective To describe the clinical features and outcome of hydroxychloroquine HCQ-induced pigmentation in patients with systemic lupus erythematosus SLE. Find information about common, infrequent and rare side effects of Plaquenil Oral. In hyperpigmentation, the skin either produces too much pigment or the pigment is deposited deep within the skin, resulting in dark spots. When color is lost, it's called hypopigmentation, which.