Her rheumatologist instructed her to undergo a baseline ocular examination prior to initiating Plaquenil (hydroxychloroquine, Sanofi-Aventis) therapy. Toxic maculopathy associated with chloroquine use was first documented in the literature five decades ago.1 In the United States, Plaquenil––an analog to chloroquine––is used to treat a variety of conditions, including rheumatoid arthritis, lupus and several distinct inflammatory disorders. Although the incidence of macular toxicity is infrequent with Plaquenil use (at a dosage of 200mg or 400mg q.d.), its visual impact can be devastating. Metronidazole and levofloxacin and hydroxychloroquine Generic pill hydroxychloroquine photo Do I need a prescription for hydroxychloroquine Plaquenil? What are the side effects of hydroxychloroquine Plaquenil? What is the dosage for hydroxychloroquine Plaquenil? Which drugs or supplements interact with hydroxychloroquine Plaquenil? Is hydroxychloroquine Plaquenil safe to take if I'm pregnant or breastfeeding? High-risk patients would include those who have taken high doses of Plaquenil for years i.e. 1000 g. for over 7 years. are 60 years or older. are obese. have significant liver or kidney disease. have pre-existing retinal, macular disease, or cataracts. Retinal damage. Plaquenil may cause irreversible damage to the retina the back of the eye where vision is created. You are required to have an eye exam before taking Plaquenil, then a follow-up as often as needed while taking Plaquenil. Tell your healthcare provider right away if you have some or all of the following symptoms. Initially, central visual acuity may be unaffected, but the patient may notice related paracentral scotomas that often interfere with reading. The associated classic retinal toxicity is described as a bull’s eye maculopathy (ring of depigmented retinal pigment epithelium that spares the foveal area). How often do you take plaquenil Plaquenil Uses, Dosage & Side Effects -, Taking Plaquenil for Rheumatoid Arthritis Hydroxychloroquine side effects rashChloroquine side effects anxietyPlaquenil for sarcoidosisGranulomatous nodules treated with plaquenil Recent findings suggest that Plaquenil toxicity can develop among patients that are taking the drug at a daily dose lower than the suggested “safe” dose and/or have been on Plaquenil for shorter than five years. The Risk of Retinal Toxicity with Plaquenil. Plaquenil - Side Effects, Uses, Dosage, Overdose.. DMARDs for Treating Rheumatoid Arthritis. Her medical history was significant for Plaquenil therapy spanning 12 years with a daily dose of 200mg twice daily. She presented with a best-corrected visual acuity of 20/20 OD and 20/20 OS. All preliminary testing revealed normal findings. Two months, but it may take up to six months before full benefits of this medication are experienced. Although there are few drug interactions with hydroxychloroquine, to be safe be sure to tell your doctor about all of the medications you are taking, including over-the-counter drugs and natural remedies. Be sure to notify your other physicians. Plaquenil toxicity isn’t even in the top 10, or the top 100” if you’re looking at incidence, he said. “It’s a pretty rare thing.” Nevertheless, he urged doctors to master the Academy’s new guidelines, because the effects from chloroquine and hydroxychloroquine, when they do occur, are severe and often irreversible.