It is generally well tolerated, but retinopathy is a concern. Retinopathy is rare, but is sight threatening, generally irreversible and may progress even after cessation of therapy. Although a number of risk factors have been proposed (such as duration of therapy and cumulative dose), the many exceptions (e.g. How do you know if plaquenil is working Is plaquenil with robaxin 500 mg Toxicity from hydroxychloroquine may be seen in two distinct areas of the eye the cornea and the macula. The cornea may become affected relatively commonly by an innocuous cornea verticillata or vortex keratopathy and is characterized by whorl-like corneal epithelial deposits. These changes bear no relationship to dosage and are usually. Cornea verticillata, also called vortex keratopathy or whorl keratopathy, is a condition characterised by corneal deposits at the level of the basal epithelium forming a faint golden-brown whorl pattern. It is seen in Fabry disease or in case of prolonged amiodarone intake. Causes. Amiodarone Fabry’s disease Chloroquine Hydroxychloroquine We report a case of previously unsuspected myeloma, presenting with cornea verticillata due to intracorneal paraprotein 85-year-old female presented via her optician with a 4-month history of cloudy vision. She had undergone an uneventful. Novel technologies such as optical coherence tomography (OCT), fundus autofluorescence (FAF) and multifocal electroretinogram (mf ERG) may provide the earliest structural and functional evidence of toxicity in these stages. Retinopathy on low-dose HCQ, or no retinopathy after a very large cumulative dose of HCQ) highlight our limited understanding of the disease process. Cornea verticillata hydroxychloroquine Drug-induced corneal epithelial changes - ScienceDirect, Cornea verticillata - Wikipedia Prescribing information and chloroquineNf54 chloroquine ic50Plaquenil cardiacChloroquine diphosphate salt sigma solubility The cornea may become affected relatively commonly by an innocuous cornea verticillata or vortex keratopathy and is characterized by whorl-like corneal epithelial deposits. These changes bear no relationship to dosage and are usually reversible on cessation of hydroxychloroquine. The macular changes are potentially serious. Hydroxychloroquine - Wikipedia. Cloudy corneas as an initial presentation of multiple myeloma. COPE Disclosures Plaquenil Toxicity Update. Rarely, they report colored rings around lights, haloes and glare which are worse at night. The condition is reversible with discontinuation of the drug. Notably other medications may also cause corneal verticillata including chloroquine and hydroxychloroquine, indomethacin, and phenothiazines and is also seen in Fabry’s disease. Corneal deposits called vortex keratopathy or corneal verticillata result from binding to cellular lipids and deposition of the drug in the basal epithelial layer of the cornea. Discontinuation of the drug usually causes the deposits to disappear over time. The aminoquinolones chloroquine and hydroxychloroquine have been widely used in the treatment of SLE. These drugs can cause a reversible, visually insignificant keratopathy cornea verticillata and, more importantly, an irreversible sight-threatening maculopathy. Clinical progression is of loss of the foveal reflex followed by a fine granular.