What is the mechanism of action of chloroquine and primaquine

Discussion in 'Canada Pharmaceuticals Online' started by magno, 16-Mar-2020.

  1. LHAV New Member

    What is the mechanism of action of chloroquine and primaquine

    Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it.

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    Mechanism of action Primaquine is lethal to P. vivax and P. ovale in the liver stage, and also to P. vivax in the blood stage through its ability to do oxidative damage to the cell. However, the exact mechanism of action is not fully understood. The inhibitory effect of chloroquine and quinine on the formation and time-course of the PQ 5,6-orthoquinone generated from racemic PQ a and its individual enantiomers b, c by CYP2D6; and on the formation of primaquine alcohol from CYP2D6-catalyzed metabolism of racemic PQ d and its enantiomers e, f. Chloroquine mechanism of drug action and resistance in Plasmodium falciparum. Slater AF1. Author information 1Picower Institute for Medical Research, Manhasset, NY 11030. Quinoline-containing drugs such as chloroquine and quinine have had a long and successful history in antimalarial chemotherapy.

    The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead.

    What is the mechanism of action of chloroquine and primaquine

    Primaquine – Malaria Site, Pathway-specific inhibition of primaquine metabolism by chloroquine/quinine

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  6. Mechanism of Action of Primaquine 7.5mg Primaquine is an 8-aminoquinoline antimalarial which eliminates the exoerythrocytic forms of malarial parasite P.vivax, P. falciparum by disrupting mitochondria and binding to DNA. By this action primaquine achieves radical cure of vivax malaria. It is also active against gametocytes of P.falciparum.

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    • Chloroquine mechanism of drug action and resistance in..
    • Mechanisms of drug action and resistance.

    In this video, I will explain into one of the main antimalarial drug, chloroquine. Chloroquine is a medication used to prevent and to treat malaria in areas where malaria is known to be sensitive. Primaquine's mechanism of action is not well understood. It may be acting by generating reactive oxygen species or by interfering with the electron transport in the parasite. Also, although its mechanism of action is unclear, primaquine may bind to and alter the properties of protozoal DNA. Mode of Action of Primaquine Preferential Inhibition of Protein Biosynthesis in Bacillus megaterium. This article has been cited by other articles in PMC. Abstract. The growth of a strain of Bacillus megaterium was prevented by a minimal inhibitory concentration of primaquine of 52 μg/ml or 2 × 10 −4m.

  7. Vanags Guest

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  8. Artemsmed Guest

    Coronavirus treatment Trump asks FDA to see if malaria drug. President Trump said he directed the FDA to investigate whether an existing drug for malaria can be used to treat the coronavirus. Some scientists have said the anti-malaria drug chloroquine could.

    Chloroquine - Wikipedia
  9. anapa-koldun Guest

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