Trametinib and hydroxychloroquine

Discussion in 'Canada Pharmaceuticals Online' started by 555five, 29-Feb-2020.

  1. krbmoney New Member

    Trametinib and hydroxychloroquine


    Researchers from Huntsman Cancer Institute (HCI) at the University of Utah have now come up with a potential new therapy for pancreatic cancer patients. The researchers have found that a new combination therapeutic approach can effectively fight the disease and prolong survival among patients.

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    Apr 10, 2019 Plaquenil hydroxychloroquine belongs to a group of medicines called quinolines. Plaquenil is used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia. Insufficient data are available in pregnant women exposed to trametinib to assess the risk. Trametinib was embryotoxic and abortifacient in rabbits at doses greater than or equal to those resulting in exposures ~0.3 times the human exposure at the recommended clinical dose. Advise patients of the potential risk to the fetus. Contraception Trametinib and Hydroxychloroquine in Treating Patients With Pancreatic Cancer THREAD The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U. S. Federal Government.

    The results of the study were published in the latest issue of the journal The team has opened up the therapy for clinical trials at HCI as well as other centres across United States along with support from University of California, San Francisco, and Columbia University in New York. The therapy has shown promise in the laboratory set up and now is ready for use among human patients in its clinical trials.

    Trametinib and hydroxychloroquine

    Dabrafenib, Trametinib and Hydroxychloroquine in Patients With Advanced., Mekinist trametinib dosing, indications, interactions.

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  7. METHODS Patients with stage IV metastatic melanoma and BRAF V600E mutations n = 11, 31-68 years of age were included. Treatment was with oral dabrafenib, 150 mg bid, trametinib, 2 mg/day, and HCQ, 400 mg to 600 mg bid.

    • FREQUENT SUBCLINICAL MACULAR CHANGES IN COMBINED BRAF/MEK..
    • Trametinib and Hydroxychloroquine in Treating Patients With Pancreatic..
    • Hydroxychloroquine Side Effects, Dosage, Uses, and More.

    Urine hydroxychloroquine levels were still detectable after 3 months with approximately 10% of the dose excreted as the parent drug. Results following a single dose of a 200 mg tablet versus i.v. infusion 155 mg, demonstrated a half-life of about 40 days and a large volume of distribution. The therapy would use a combination of two FDA Food and Drug Administration approved drugs that are currently being used for other types of cancer – namely trametinib and hydroxychloroquine. Hydroxychloroquine is usually taken with food or milk to prevent stomach upset. The dosage and length of treatment are based on your medical condition and response to therapy. In children, dosage.

     
  8. giptunnilkigh XenForo Moderator

    Hydroxychloroquine is used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Plaquenil side effects - kidney problems? - Symptoms - Life. Will you have High blood pressure with Plaquenil - eHealthMe Drugs that increase blood pressure - Open Access Journal
     
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