Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Hydroxychloroquine mechanism of action in lupus Gluten free plaquenil Can you take tramadol with hydroxychloroquine Three anti-malarial drugs are prescribed for lupus symptoms. Hydroxychloroquine Plaquenil is the most commonly prescribed because it is generally believed to cause fewer side effects; chloroquine Aralen has a reputation for more serious side effects, but it may be prescribed in situations where hydroxychloroquine cannot be used. Thanks. for the info. i feel so so so bad. It has been going on for years but it seems worse since spring/summer started. my ra factor has been negative. the only thing coming back postive at this point is my ANA which i believe is speckled & homogenous. The first rheum wrote me off and told me I had nothing,this was 2004! User Reviews for Hydroxychloroquine. Also known as Plaquenil, Quineprox The following information is NOT intended to endorse any particular medication. While these reviews might be helpful, they are not a substitute for the expertise, skill, knowledge and judgement of healthcare practitioners. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Hydroxychloroquine makes me feel worse Plaquenil Side Effects Common, Severe, Long Term -, Hydroxychloroquine plaquenil ProHealth Fibromyalgia, ME/CFS and. Plaquenil pill shapeChloroquine phosphate in display tank Hydroxychloroquine is used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America. Hydroxychloroquine - Side Effects, Dosage, Interactions.. User Reviews for Hydroxychloroquine -. Hydroxychloroquine Side Effects, Dosage, Uses, and More. I can only speak for myself and my personal experience. Plaquenil has helped me on many levels on many days. I think, for me, anyway, the depression and anxiety I often feel is due to the autoimmune issues/sjogrens. I have not noticed an increase in depression/anxiety since being on the plaquenil but that is just me. On plaquenil always made me feel very bad. hate it. before my diagnosis I was tired,aneamic,stiff etc since the plaquenil I jus flare all the time. it was so bad I just came off it for several months. got so ill they wanted me to go on chemo based drugs but I did not want that either. so reluctantly went back on the plaquenil. imo its made me worse. I asked her for plaquenil since it's a non steroid anti inflammatory. She seemed hesitant to prescribe it. She told me that it could make me feel better or much much worse. She said after 3 days of burbur detox I could try 1/2 tablet of plaquenil every other day, but if i start feeling worse to stop immediately.