Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Chloroquine davis Hydroxyzine chloroquine Weight loss methotrexate and plaquenil Note This document contains side effect information about hydroxychloroquine. Some of the dosage forms listed on this page may not apply to the brand name Plaquenil. For the Consumer. Applies to hydroxychloroquine oral tablet. Along with its needed effects, hydroxychloroquine the active ingredient contained in Plaquenil may cause some unwanted effects. Alopecia areata is an autoimmune condition resulting in hair loss and complete baldness alopecia totalis. Published evidence says that it is mediated by T-lymphocytes. Plaquenil is an anti-inflammatory drug approved by the FDA for malaria, lupus erythematosus, and rheumatoid arthritis. Jun 15, 2017 Treatment depends on how much of the scalp is affected and how quickly the condition progresses. A high or moderate potency steroid cream is often effective in treating lichen planopilaris. If this is not effective, steroid injections into skin lesions, or systemic corticosteroids taken by mouth may be considered. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. How can plaquenil scarring alopecia Scarring Alopecia Treatment & Management Medical Care., Plaquenil for Alopecia Areata, Alopecia Totalis - Full. Plaquenil patient assistance canadaHydroxychloroquine and ranitidinePlaquenil and coffeeChloroquine rheumatoid arthritis mechanism of action In general patients with lichen planopilaris may have itching of the scalp and some may have increased hair shedding. They may also have burning, pain and tenderness in the scalp. Some patients note that the scalp is tender when the hairs are moved. There may be redness in the scalp and some scale. Lichen Planopilaris — Canadian Hair Loss Foundation. Lichen planopilaris Genetic and Rare Diseases Information.. Hydroxychloroquine Plaquenil and Hair Loss Is my.. If that isn't an option, go to a doctor. If it isn't that deeply grown in, removal is fairly simple. If it is and that's what they're designed to do -- grow into your tissue, the piercer or MD will use a scalpel to remove it. The scarring should be minimal. You are supposed to have a blood test every month to check on your liver and kidneys as long term use can affect them. I was told also to keep an eye out for 'floaters' in my eyes, as Plaquenil can cause macular damage to your retinas. I'm only on a low dose, but now have a black line floating over my eye. Hydroxychloroquine Plaquenil is a slow acting drug. It can take up to 8 weeks or more before the medication really starts to have an effect and actually help an individual using the drug. Because hydroxychloroquine is so delayed in its onset, I usually give it 4-6 months before really deciding if it is working. and sometimes even longer.