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Indomethacin is used to relieve moderate to severe pain, tenderness, swelling, and stiffness caused by osteoarthritis arthritis caused by a breakdown of the lining of the joints, rheumatoid arthritis arthritis caused by swelling of the lining of the joints, and ankylosing spondylitis arthritis that Some drugs can be dangerous when mixed. Talk to a doctor or pharmacist if you are taking more than one drug. This includes over-the-counter medication and herb or dietary supplements. Plan ahead for refills so you don’t run out. However, as with any medication, there are both risks and benefits, and people should be careful before turning to a bottle to address their symptoms.