So far I have no more energy than when I first started and has developed neuropathy which I have just found out from Web MD that this neuropathy is one of the side effects of this med! Saying that by stopping this it would take another 6 months to build up the benefit. There are other meds that can help with what you are experiencing, and if your doctor didn't address that then I would seek out a second opinion... Please don't stop your plaquenil until you are sure it is the right thing to do and in your best interest. Hydroxychloroquine plaque psoriasis Chloroquine reduce cell viability Does plaquenil help neuropathy Plaquenil is a brand name of Hydroxychloroquine. You can crush Plaquenil, there is no contraindications for crushing it. It is even crushed and given through Nasogastric tube. Splitting tablets in half is a practice that some patients, employers, healthcare providers, and even health insurance and managed care companies are now recommending. Tablet splitting under the direction of a healthcare provider can be safe and save you money, too. Overall Plaquenil did take away the muscle and joint pain. It worked wonders for that. For that reason I am satisfied with plaquenil for what I took it for. Took about 5-6 months to see full effect. Since reducing the dose from 400mg to 200mg 4 months ago I do feel some of this pain returning You win some, you lose some! M 49 1 years 400mg day Plaquenil is a 6-weeker as far as the benefits are concerned, but it would be more dangerous to stop if you spend a lot of time outside and if this were the summer. Or maybe another doctor if you're not comfortable w/your current one. Can you break plaquenil in half Cutting Pills in Half Could Pose Problems, Pill Splitting - A Safe Way to Save Healthcare Dollars? Hydroxychloroquine side effects weight gainPlaquenil and antiplatelet drugs Most time-released, long-acting, and combination drugs shouldn’t be split because it’s difficult to make sure that you’ll get the proper amount of the active ingredient in each half. When It's Safe to Split Pills - Consumer Reports. PLAQUENIL Side Effects, Reviews by Patients -. I'm scared to take plaquenil.. Plaquenil is a 6-weeker as far as the benefits are concerned, but it would be more dangerous to stop if you spend a lot of time outside and if this were the summer. If you're gonna experiment, I went off it cold turkey as it didn't hurt to do it that way, but you better get back on before the summer or you could experience a flare-up. I wouldn't break them in half, the medication that comes in a single pill without score mark, shouldn't be crushed or broken in half. You should check with your pharmacist though Reply I say this because Plaquenil has a chemical half-life of 30-60 days you can confirm this on wiki or RX info on the drug--so it takes a LONG time to get out of your system.long for you to notice changes in days. If you remember, most wait at least 3 months before they even see any improvement.