Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking chloroquine: Incidence not known Some side effects of chloroquine may occur that usually do not need medical attention. Plaquenil arthritis medication Hydroxychloroquine lung disease Plaquenil cumulative dose toxicity Plaquenil primary biliary cirrhosis Exacerbations of bipolar disorder triggered by chloroquine in systemic lupus erythematosus—a case report J Bogaczewicz, T Sobów, A Bogaczewicz, E Robak, P Bienkowski, A Sysa-Jędrzejowska, and A Woźniacka Aug 21, 2018 Hydroxychloroquine and chloroquine phosphate have shown beneficial effects in treating discoid lupus erythematosus DLE. Additionally, The antimalarial drugs may prevent the development of systemic lupus erythematosus SLE in patients with DLE, and they might decrease the risk of cardiovascular disease. Chloroquine is a medication used to prevent and to treat malaria in areas where malaria is known to be sensitive to its effects. Certain types of malaria, resistant strains, and complicated cases typically require different or additional medication. It is also occasionally used for amebiasis that is occurring outside the intestines, rheumatoid arthritis, and lupus erythematosus. It is taken by mouth. Common side effects include muscle problems, loss of appetite, diarrhea, and skin rash. Serious Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Chloroquine systemic lupus erythematosus Treating Lupus with Anti-Malarial Drugs Johns Hopkins., Discoid Lupus Erythematosus Medication Antimalarial agents. Plaquenil qt prolongation Systemic lupus erythematosus; treatment; disease activity; We thank Drs Figueroa-Parra et al for their interest in our paper1 and their comment regarding the value of chloroquine CQ as an alternative antimalarial in systemic lupus erythematosus SLE.2 As the authors point out, there are data, mostly for older studies, to support the efficacy of CQ in SLE.3 Nevertheless, over the last 20. Chloroquine as alternative antimalarial in systemic lupus.. Chloroquine - Wikipedia. UpToDate. Borden MB, Parke AL 2001 Antimalarial drugs in systemic lupus erythematosus use in pregnancy. Drug Saf 55–1063 PubMed CrossRef Google Scholar Boström H, Moretti A, Whitehouse M 1963 Studies of the biochemistry of heart valves. On the biosynthesis of mucopolysaccharides in bovine heart valves. Lupus Systemic Lupus Erythematosus - an easy to understand guide covering causes, diagnosis, symptoms, treatment and prevention plus additional in depth medical information. Patients with systemic lupus erythematosus have higher levels of homocysteine, a known risk factor for atherosclerosis.15 Intervention, in the form of both lifestyle modifications and.