Leflunomide, sulfasalazine, and hydroxychloroquine are effective therapies in RA and are commonly employed in combination therapy. Although the precise mechanisms of action of the traditional DMARDs are incompletely understood, most have both anti-inflammatory and immunomodulatory actions. Hydroxychloroquine for low platelets Plaquenil and weight gain forum Conventional DMARDs that have been paired with methotrexate include sulfasalazine, hydroxychloroquine, cyclosporine, leflunomide and azathioprine. Although studies of these combinations have shown differing levels of benefit, the combinations of methotrexate plus leflunomide and methotrexate plus sulfasalazine are among the most effective. Background/Purpose The combination of methotrexate MTX, sulfasalazine SSZ and hydroxychloroquine HCQ triple therapy is a highly effective and well-tolerated treatment in rheumatoid arthritis RA. While MTX is the cornerstone of most successful combination therapies, not all patients are candidates for, or tolerate, MTX. Leflunomide, a disease-modifying anti-rheumatic drug DMARD. CHICAGO – Combination therapy with leflunomide and hydroxychloroquine met all goals for efficacy, safety, and tolerability among patients with primary Sjögren’s syndrome in a randomized, placebo-controlled pilot study, lending support to evidence suggesting the two drugs have additive benefits. Toxicity from DMARD therapy can cause significant morbidity and rarely mortality; thus, appropriate dosing and monitoring for toxicity are essential. Choice of DMARD therapy should be tailored to the individual patient, with attention given to age, fertility plans, concomitant medications, and comorbidities. Leflunomide hydroxychloroquine combination Hydroxychloroquine oral and leflunomide oral Drug Interactions - RxList, Leflunomide, Sulfasalazine and Hydroxychloroquine for Rheumatoid. Chloroquine diphosphate salt sigma solubility The efficacy of hydroxychloroquine as a step-down therapy from methotrexate- hydroxychloroquine combination therapy has also been investigated; after 24 weeks of open treatment, 121 patients who responded to methotrexate- hydroxychloroquine combination therapy 7.5-15 mg/week and 400 mg/day, respectively were randomly assigned to receive. Combination Therapy for Rheumatoid Arthritis. Leflunomide-hydroxychloroquine combo shows promise in primary Sjögren’s.. Combination Therapy for Rheumatoid Arthritis in the Era of.. After 2 years of taking MTX, Sulfasalazine and Hydroxychloroquine in combination my new Rheumy has determined that there aren't having enough effect as a combination and wants to take me off the Sulfa and substitute Leflunomide. Combination Therapy for Rheumatoid Arthritis. It can be used with another drug in its class such as hydroxychloroquine, leflunomide, and sulfasalazine or with a biologic drug. I have ra, am taking leflunomide 20 mg, prednisone 2.5 and plaquenil hydroxychloroquine 200 mg. I don't have in more I have ra, am taking leflunomide 20 mg, prednisone 2.5 and plaquenil hydroxychloroquine 200 mg. I don't have ins.